{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:16:32Z","timestamp":1763036192278,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; It is well known that fluorouracil (FU) agents frequently induce discoid-lupus-erythematosus (DLE)-like eruptions and acral erythema in Japan. However, the etiology of these drug eruptions caused by FU agents has not been clarified yet. &lt;i&gt;Objective:&lt;\/i&gt; To determine if the existence of anti-SSA\/Ro antibody may be a risk factor for FU-agent-induced DLE-like eruptions and acral erythema. &lt;i&gt;Patients and Methods:&lt;\/i&gt; Six patients with FU-agent-induced drug eruptions showing DLE-like lesions and acral erythema were enrolled in this study. The titers of anti-SSA\/Ro antibody in the sera and the histopathology of the skin lesions were examined. &lt;i&gt;Results:&lt;\/i&gt; Biopsy specimens from DLE-like eruptions and all 5 examined acral erythema cases showed lichenoid change of the basal keratinocytes. Direct immunofluorescence studies revealed deposition of immunoglobulins along the basement membrane zone in the lesions of both DLE-like eruptions and acral erythema. Further, all 6 cases had high titers of serum anti-SSA\/Ro antibody, which did not decline within 6 months after cessation of the causative drug. &lt;i&gt;Conclusion:&lt;\/i&gt; We propose that anti-SSA\/Ro antibody may be a risk factor for FU-agent-induced drug eruptions showing acral erythema and DLE-like eruptions.<\/jats:p>","DOI":"10.1159\/000096919","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T23:18:32Z","timestamp":1166829512000},"page":"85-88","source":"Crossref","is-referenced-by-count":21,"title":["Anti-SSA\/Ro Antibody as a Risk Factor for Fluorouracil-Induced Drug Eruptions Showing Acral Erythema and Discoid-Lupus-Erythematosus-Like Lesions"],"prefix":"10.1159","volume":"214","author":[{"given":"Atsuko","family":"Adachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Horikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2891%2970073-B"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0190-9622%2893%2970187-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.1.45"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000086440"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2889%2980031-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.114565"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000089024"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.autrev.2005.01.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2004.02458.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:58:09Z","timestamp":1745463489000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,22]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096919","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2006,12,22]]}}}