{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:14:45Z","timestamp":1791994485871,"version":"4.4.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>The age distribution of the &amp;#917;4 allelic form of the apolipoprotein E gene &lt;i&gt;(APOE)&lt;\/i&gt; was investigated in 630 patients with Alzheimer\u2019s disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4 allele was later than that in those EOAD cases without &amp;#917;4 allele, whereas in LOAD mean age at onset in cases bearing &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4 allele was earlier than in those without &amp;#917;4 allele. When analysed by decade, it was observed that 37% of the total number of &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4 allele bearers, and 43% of total number of cases with &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4\/&amp;#917;4 genotype fell into the 60\u201369 years age class. Hence, &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4 allele frequency, at 0.44, was highest in the 60\u201369 years age class, progressively decreasing either side of this age group. &lt;i&gt;APOE&lt;\/i&gt; &amp;#917;4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.<\/jats:p>","DOI":"10.1159\/000097038","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:36:09Z","timestamp":1163637369000},"page":"60-66","source":"Crossref","is-referenced-by-count":54,"title":["Apolipoprotein E \u03b54 Allele Frequency and Age at Onset of Alzheimer\u2019s 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