{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:15Z","timestamp":1785499815203,"version":"3.56.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T00:00:00Z","timestamp":1163980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,11,20]],"date-time":"2006-11-20T00:00:00Z","timestamp":1163980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Patent ductus arteriosus (PDA) is frequent and potentially pathologic in preterm infants. A simple bedside tool to screen for ductal patency would assist in the care of extremely low birth weight (ELBW) infants. <i>Objective:<\/i> To investigate the utility of near-infrared spectroscopy (NIRS) in identifying ELBW infants who would benefit from early echocardiography. <i>Methods:<\/i> Tissue oxygen saturation (S<sub>t<\/sub>O<sub>2<\/sub>) was measured by NIRS in the lungs, brain, skeletal muscle and kidney of 20 ELBW infants. Comparisons were made between the S<sub>t<\/sub>O<sub>2<\/sub> in these organs and the need for intervention for a PDA. All studies were performed within the first 4 days of life. Similar measurements were performed following treatment with indomethacin in nine of the patients. <i>Results:<\/i> The S<sub>t<\/sub>O<sub>2 <\/sub>of skeletal muscle (left deltoid) and kidney differed between the infants who were treated for PDA and those who were not (p = 0.01 for both). As a screen for a PDA requiring intervention, deltoid S<sub>t<\/sub>O<sub>2<\/sub> had sensitivity 77% and specificity 83%, and kidney S<sub>t<\/sub>O<sub>2<\/sub> had sensitivity 85% and specificity 83%. Following treatment with indomethacin, the low S<sub>t<\/sub>O<sub>2<\/sub> in the deltoid and kidney increased toward the range seen in patients who did not require treatment of a PDA. Inter- and intra-observer variability ranged from minimal to high. <i>Conclusion:<\/i> This pilot study of a portable NIRS device shows encouraging efficacy in identifying ELBW infants who were likely to benefit from early echocardiography and subsequent intervention to close a PDA. Further study is warranted.<\/jats:p>","DOI":"10.1159\/000097131","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T10:07:49Z","timestamp":1164622069000},"page":"134-139","source":"Crossref","is-referenced-by-count":61,"title":["Near-Infrared Spectroscopy as a Screening Tool for Patent Ductus Arteriosus in Extremely Low Birth Weight Infants"],"prefix":"10.1159","volume":"91","author":[{"given":"Mark A.","family":"Underwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Milstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2892%2990179-K"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2004.057638"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970362-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.6.1345"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-200X.2003.01713.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-3016.1988.tb00227.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ultrasmedbio.2004.10.006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1084-2756%2803%2900121-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00008480-200404000-00005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.siny.2004.10.003"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.88.1.85"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.5.e354"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Ffn.88.6.F477"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.2005.030"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970172-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2003.027698"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2000.105234"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1837"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.03.040"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10877-005-1655-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001340100994"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Ffn.88.4.F263"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2890%2993030-S"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200001000-00009"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1114%2F1.1359451"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:00:12Z","timestamp":1745463612000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,20]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097131","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,20]]}}}