{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:39:06Z","timestamp":1770910746614,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T00:00:00Z","timestamp":1164758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T00:00:00Z","timestamp":1164758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> There is insufficient data to reliably assess the benefit of bronchodilators in ventilated premature neonates. <i>Objectives:<\/i> To compare the efficacy\/tolerance of inhaled ipratropium bromide (IB) vs. terbutaline (T) and to describe factors associated with their efficacy. <i>Methods:<\/i> A cross-over randomized controlled double-blind trial including intubated neonates with respiratory distress syndrome. Two puffs of IB or T were administered at 0, 20, 40 min. Passive respiratory system resistance (Rrs) and compliance (Crs) were measured at 0, 20, 40, 60 min. A positive response was defined as a >2 individual coefficients of variation decrease in Rrs or increase in Crs. <i>Results:<\/i> Twenty-one infants (gestational age (mean \u00b1 SD): 27.3 \u00b1 1.6 weeks; birth weight: 947 \u00b1 250 g; postnatal age: 20 \u00b1 9 days) were included. At 60 min, no treatment effect for Rrs and Crs could be identified (cross-over analysis). Overall data (irrespective of order of administration) showed that after 6 puffs, the decrease in Rrs was greater in the IB vs. T group (\u201317.0 \u00b1 22.2% vs. \u201311.3 \u00b1 26.7%, respectively (NS)). Thirty-eight percent of infants responded to IB vs. 43% to T. However, in 19% of patients, decreased Crs was observed after 6 puffs of T. No marker of a positive or paradoxical response could be identified. Treatment was well-tolerated. <i>Conclusion:<\/i> High doses of bronchodilators are required in ventilated neonates, but the positive response rate was <50%. Their long-term benefit remains to be proven.<\/jats:p>","DOI":"10.1159\/000097448","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:39:49Z","timestamp":1164976789000},"page":"167-173","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and Tolerance of High-Dose Inhaled Ipratropium Bromide vs. Terbutaline in Intubated Premature Human Neonates"],"prefix":"10.1159","volume":"91","author":[{"given":"Michael","family":"Fayon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawar","family":"Tayara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Germain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Luce","family":"Choukroun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Dumas De La Roque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Ch\u00eane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Breilh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Marthan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Demarquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2897%2970241-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200110000-00015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.168.3.356"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2889%2980755-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050969"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2896%2970357-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.88.1.88"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2878%2980282-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000067015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.01.17101410"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000241098"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-6576.1981.tb01654.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-200003000-00037"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fbja%2F68.1.27"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-2123"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-0496%28199706%2923%3A6%3C442%3A%3AAID-PPUL8%3E3.0.CO%3B2-K"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-0496%28199605%2921%3A5%3C301%3A%3AAID-PPUL5%3E3.0.CO%3B2-P"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-0496%28199903%2927%3A3%3C208%3A%3AAID-PPUL10%3E3.0.CO%3B2-A"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2001-14526"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2916941-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2887%2980087-2"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:03:35Z","timestamp":1745463815000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,29]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097448","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,29]]}}}