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Many therapeutic options are available to delay progression, including autologous and allogeneic bone marrow transplantation. At advanced stages, MM is often refractory to treatment. We report a heavily pretreated patient with graft-versus-host disease after bone marrow transplantations, treated at a terminal stage with a modified protocol for arsenic trioxide (ATO). This patient with poor clinical status tolerated the treatment very well. He had a remarkable clinical response and achieved complete remission. The mechanisms of ATO are presented and the potential role of ATO for MM is discussed.<\/jats:p>","DOI":"10.1159\/000097457","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:39:49Z","timestamp":1164976789000},"page":"119-121","source":"Crossref","is-referenced-by-count":2,"title":["A Patient with Progressive Multiple Myeloma Treated Successfully with Arsenic Trioxide after Allogeneic Bone Marrow Transplantation"],"prefix":"10.1159","volume":"117","author":[{"given":"B.","family":"Gesundheit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Y.","family":"Shapira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ackerstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.B.","family":"Resnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bitan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Or","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra041875"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.6-suppl_2-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.6-suppl_2-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc887"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190412331272686"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080%2F1042819021000002857"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fshem.2002.33611"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.seminoncol.2004.02.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2403021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.10.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2004.04941.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2402599"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V98.3.805"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00280-003-0692-y"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F31.1.161"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F30.4.535"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109%2F08982109309150730"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000092341"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.6-suppl_2-17"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:03:39Z","timestamp":1745463819000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,29]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097457","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2006,11,29]]}}}