{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:55:18Z","timestamp":1791406518529,"version":"4.3.3"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T00:00:00Z","timestamp":1164758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T00:00:00Z","timestamp":1164758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background\/Aim: <\/i>To report our experience of paediatric renal transplantation at Great Ormond Street and Royal Free Hospitals since the inception of the programme. <i>Methods:<\/i> Retrospective review of the patient and transplant survival and influencing factors in the 300 children transplanted between 1973 and 2000. <i>Results:<\/i> 300 children had received a total of 354 transplants; 56 were living-related donations. The median age at transplantation was 10.3 (range 1.4\u201317.9) years. Forty-four percent had congenital structural abnormalities of the urinary tract. Forty-six children required a second and 8 a third transplant before transfer to an adult unit. The overall patient survival at 5, 10, and 20 years was 97, 94, and 72%, respectively. In the overall cohort, the donor type (deceased donor or living-related donor) did not affect mortality, nor did age at transplantation, but those transplanted before 5 years of age had a significantly shorter post-transplant survival time (p < 0.0001). Transplant survival (first transplant) for deceased and living-related donors was 66 and 87% at 5 years (p < 0.01), 51 and 54% at 10 years, and 36% at 20 years (deceased-donor transplants only). Although the overall transplant survival was inferior in children transplanted before 2 years of age (p < 0.03), in the most recent cohort (1990\u20132000), age did not affect the outcome. On multiple regression analysis, the only predictor of transplant survival was the era of transplantation (p < 0.001). The median final height was within the normal range for males and females; 7 patients received growth hormone after transplantation. <i>Conclusions:<\/i> The outlook for successful transplantation is improving, and in the last decade was unaffected by age at transplantation. The survival of living-related donor transplants is superior to deceased-donor transplants for the first 5 years. From the above data, we can predict that a 10-year-old child receiving a renal transplant in 2000 and on ciclosporin-based immunosuppression can expect a transplant half-life of 13.1 years from a living-related donor and one of 10.8 years from a deceased-donor transplant.<\/jats:p>","DOI":"10.1159\/000097601","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:39:49Z","timestamp":1164976789000},"page":"c68-c76","source":"Crossref","is-referenced-by-count":56,"title":["Long-Term Outcome of Paediatric Renal Transplantation: Follow-Up of 300 Children from 1973 to 2000"],"prefix":"10.1159","volume":"105","author":[{"given":"Lesley","family":"Rees","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukshana","family":"Shroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswald N.","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Trompeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2004.11.026"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00156.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00356.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000128616.02821.8B"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.tp.0000168090.19875.b0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3046.2002.02042.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000092524.75807.84"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000120947.75697.8B"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3046.2001.00137.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031643"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3046.2001.t01-1-00008.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-005-1878-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00852871"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02125798"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199009000-00014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670050689"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2004.12.016"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3046.2002.02027.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-005-1896-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00013.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.arcped.2004.03.129"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.85.6.478"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3046.2003.00068.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-6143.2002.21010.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200009283431304"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-005-1952-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199107000-00010"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:05:06Z","timestamp":1745463906000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,29]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097601","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,29]]}}}