{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:19:12Z","timestamp":1770887952299,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Toxic epidermal necrolysis (TEN) is a dramatic drug-induced emergency related to extensive destruction of the epidermis. There is evidence that its pathomechanism involves impaired detoxication of xenobiotics. Glutathione-S-transferase \u03c0 (GST-\u03c0) is a phase II detoxifying enzyme involved in drug metabolization by human keratinocytes. &lt;i&gt;Method:&lt;\/i&gt; Immunohistochemistry was performed in order to assess the expression of GST-\u03c0 in keratinocytes of TEN, other cutaneous adverse drug reactions and bullous pemphigoid. &lt;i&gt;Results:&lt;\/i&gt; GST-\u03c0 was disclosed in the involved epidermis of 16\/16 TEN patients. It was present in the cytoplasm of suprabasal keratinocytes. GST-\u03c0 was also expressed in the clinically uninvolved skin in a majority (8\/12) of TEN patients. By contrast, it was rarely and poorly expressed in the other tested dermatoses. &lt;i&gt;Conclusion:&lt;\/i&gt; The pathomechanism of TEN is not related to an impaired quantitative expression of GST-\u03c0. GST-\u03c0 expression is an early event in TEN. As oxidative stress is a major inducer of GST-\u03c0, this mechanism might be involved in TEN. Its GST-\u03c0 expression mainly restricted to the suprabasal keratinocytes suggests that the pathomechanisms leading to keratinocyte death in TEN are distinct at different levels of the epidermis.<\/jats:p>","DOI":"10.1159\/000097652","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:39:49Z","timestamp":1164976789000},"page":"66-70","source":"Crossref","is-referenced-by-count":18,"title":["Glutathione-S-Transferase Pi Expression in Toxic Epidermal Necrolysis: A Marker of Putative Oxidative Stress in Keratinocytes"],"prefix":"10.1159","volume":"20","author":[{"given":"P.","family":"Paquet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.E.","family":"Pi\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199512143332404"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.131.5.544"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-2797%2898%2900021-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2000.00985.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.all.0000011028.08297.b3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Ftoxsci%2F49.2.156"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12481276"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1997.d01-1197.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F10715769900300851"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.129.1.92"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.32.7.813"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.6.683"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.130.5.605"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.282.5388.490"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F18.5.1321"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1206940"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109%2F10409239509083491"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.85.21.8261"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9861%2891%2990025-E"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-2797%2801%2900277-0"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:05:22Z","timestamp":1745463922000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097652","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,1]]}}}