{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:26:12Z","timestamp":1752229572561,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,12,11]],"date-time":"2006-12-11T00:00:00Z","timestamp":1165795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,11]],"date-time":"2006-12-11T00:00:00Z","timestamp":1165795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Purpose:<\/i> It was the aim of this study to assess the expression of vascular endothelial growth factor (VEGF)-A, matrix metalloproteinase (MMP)-9 and extravascular matrix patterns (EMPs) in iris and ciliary body melanomas and their correlations with histopathologic parameters. <i>Methods:<\/i> The study was conducted on 3 iris and 15 ciliary body melanomas. All tumors were subjected to immunohistochemical techniques for VEGF-A and MMP-9 expressions, the presence of EMPs was assessed, and routine paraffin sections were stained with hematoxylin-eosin. Cell type, tumor localization, degree of pigmentation, necrosis, mitotic index, lymphocytic infiltration and sclera invasion were analyzed using light microscopy. <i>Results:<\/i> The mean patient age at the time of treatment was 43 years (range 19\u201369, median 39.5); 10 (55.6%) patients were males and 8 (44.4%) females. Histopathological cell types were spindle cells in 55.6%, mixed cells in 16.7%, and epithelioid cell types in 27.8% of tumors. Positive reaction for VEGF-A and MMP-9 was present in 66.7 and 72.3% of the tumors, respectively. Microvascular loops and\/or networks were seen in 33.4% of the tumors, with the remaining 66.7% of tumors displaying one or more of the other patterns. Metastatic disease developed in only 1 patient during follow-up. Tumor cell type, tumor size, mitotic rate, degree of pigmentation and EMPs were not correlated with metastasis. <i>Conclusions:<\/i> This study suggests that VEGF-A and MMP-9 were positive in the majority of iris and ciliary body melanomas. No correlation was found between VEGF-A and MMP-9 immunoreactivity and EMPs and occurrence of metastases in cases of anterior uveal melanoma.<\/jats:p>","DOI":"10.1159\/000097905","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T16:57:41Z","timestamp":1166029061000},"page":"40-44","source":"Crossref","is-referenced-by-count":10,"title":["Expression of Vascular Endothelial Growth Factor A, Matrix Metalloproteinase 9 and Extravascular Matrix Patterns in Iris and Ciliary Body Melanomas"],"prefix":"10.1159","volume":"39","author":[{"given":"Afsun","family":"Sahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayyam","family":"Kiratli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaye Guler","family":"Tezel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Soylemezoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgul","family":"Bilgic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00004397-199703740-00008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.1970.tb06592.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900449-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0046-8177%2892%2990299-I"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1022935117193"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1087-0024.2000.00003.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.81.6.501"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03032599"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F89.17.1260"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.86.4.440"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.84.7.750"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2965173-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2964739-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900520-0"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:25:54Z","timestamp":1745461554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,11]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097905","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2006,12,11]]}}}