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Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recent studies questioned the current categorical split of mood disorders into bipolar disorders (BP) and depressive disorders (MDD). &lt;i&gt;Methods:&lt;\/i&gt; Medline database search of papers from the last 10 years on the categorical-dimensional classification of mood disorders. Various combinations of the following key words were used: mood disorders, bipolar, unipolar, major depressive disorder, spectrum, category\/categorical, classification, continuity. Only English language clinical papers were included, review papers were excluded, similar papers selected by quality. The number of papers found was 1,141. The number of papers selected was 109. &lt;i&gt;Results:&lt;\/i&gt; The continuity\/spectrum between BP (mainly BP-II) and MDD was supported by the following findings:(1) high frequency of mixed states (mixed mania, mixed hypomania, mixed depression, i.e. co-occurring depression and noneuphoric manic\/hypomanic symptoms) because opposite polarity symptoms in the same episode do not support a hypomania\/mania-depression splitting; (2) MDD was the most common mood disorder in BP probands\u2019 relatives; (3) no bimodal distribution of distinguishing symptoms between BP and MDD; (4) bipolar signs not uncommon in MDD; (5) many MDD shifting to BP; (6) many lifetime manic\/hypomanic symptoms in MDD; (7) correlation between lifetime manic\/hypomanic symptoms and MDD symptoms; (8) hypomania factors in MDD; (9) MDD often recurrent; (10) similar cognitive style.The categorical distinction between BP (mainly BP-I) and MDD was supported by the following findings: (1) BP more common in BP probands\u2019 relatives; (2) lower age at BP onset; (3) females as common as males in BP-I, more common than males in MDD; (4) BP-I depression more atypical and retarded, MDD depression more sleepless and agitated; (5) BP more recurrent. &lt;i&gt;Conclusions: &lt;\/i&gt;Focusing on mood spectrum\u2019s extremes (BP-I vs. MDD), a categorical distinction seems supported. Focusing on midway disorders (BP-II and MDD plus bipolar signs), a continuity\/spectrum seems supported. Results seem to support both a categorical and a dimensional view of mood disorders.<\/jats:p>","DOI":"10.1159\/000097965","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T11:49:18Z","timestamp":1169207358000},"page":"70-76","source":"Crossref","is-referenced-by-count":44,"title":["Is There a Continuity between Bipolar and Depressive 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