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Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; This article reviews the rationale and data supporting alpha blocker therapy for chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS), the most common and difficult prostatitis syndrome. &lt;i&gt;Methods:&lt;\/i&gt; Systematic review identified ten clinical trials evaluating alpha blocker therapy for patients with CP\/CPPS, including five open-label or small prospective studies and five double-blinded and placebo-controlled clinical trials. &lt;i&gt;Results:&lt;\/i&gt; Encouraging results in uncontrolled and small clinical trials led to the development of reasonably powered, double-blinded, placebo-controlled, randomized clinical trials evaluating terazosin, doxazosin, tamsulosin, and alfuzosin. &lt;i&gt;Conclusions:&lt;\/i&gt; Current data suggest that treatment-na\u00efve and\/or newly diagnosed patients appear more likely to respond than long-term, chronic refractory patients. Longer courses of treatment (12 weeks to 6 months) appear superior to shorter courses, and less selective agents appear superior to more selective alpha&lt;sub&gt;1&lt;\/sub&gt; blockers. These observations outline important questions that must be answered to define optimal treatment strategies for patients with CP\/CPPS.<\/jats:p>","DOI":"10.1159\/000098064","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T16:55:23Z","timestamp":1171299323000},"page":"97-105","source":"Crossref","is-referenced-by-count":14,"title":["Chronic Prostatitis\/Chronic Pelvic Pain Syndrome: Role of Alpha Blocker Therapy"],"prefix":"10.1159","volume":"78","author":[{"given":"Shaun Wen Huey","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Men Long","family":"Liong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kah Hay","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee 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