{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:49:39Z","timestamp":1773409779996,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Das prim\u00e4re maligne Melanom der Vagina ist ein sehr seltenes Malignom mit weltweit weniger als 300 publizierten F\u00e4llen. Noch viel seltener sind Melanommetastasen in der Vagina mit bis anhin 5 beschriebenen F\u00e4llen. Bei der von uns beschriebenen Patientin zeigte sich ein von der linken Vaginalwand ausgehendes, 6 cm im Durchmesser messendes und 2,5 cm tiefes Melanom der Vagina ohne lokoregion\u00e4re Lymphknoten- oder Fernmetastasen in der Bildgebung. In der Literatur werden als Erfolg versprechendste Therapiemodalit\u00e4ten die \u00abwide local excision\u00bb mit adjuvanter Radiotherapie und die Radikaloperation mit adjuvanter Radiotherapie diskutiert, die \u00e4hnliche 5-Jahres-\u00dcberlebensraten zeigen. Zur Reduktion des doch erheblichen Risikos der Fernmetastasierung war als weiterf\u00fchrende systemische Therapie eine Immunmodulation mit Interferon-\u03b1&lt;sub&gt;2b&lt;\/sub&gt; vorgesehen, welche bei fortgeschrittenen Melanomen der Haut etabliert ist. Leider lag bei der Planung der Interferontherapie 6 Monate nach Diagnosestellung im PET-CT eine ausgedehnte Metastasierung vor, so dass anstelle der Interferontherapie eine palliative Chemotherapie mit Dacarbazine und Thalidomid durchgef\u00fchrt wurde.<\/jats:p>","DOI":"10.1159\/000098124","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T07:41:49Z","timestamp":1171266109000},"page":"39-44","source":"Crossref","is-referenced-by-count":4,"title":["Prim\u00e4res malignes Melanom der Vagina \u2013 Fallbericht und Literatur\u00fcbersicht"],"prefix":"10.1159","volume":"47","author":[{"given":"C.","family":"Betschart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"von Orelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mihic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70320-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5188"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200211000-00007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196407)17:7<912::AID-CNCR2820170711>3.0.CO;2-F"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.4982"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.06.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21189"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.7-4-271"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2002.9.7.646"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.036"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6763"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1283"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.9966"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90609-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1994.04060379.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90345-L"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:28:08Z","timestamp":1745461688000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000098124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000098124","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"value":"1018-8843","type":"print"},{"value":"1423-0011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}