{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:10:33Z","timestamp":1773681033068,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> The present study was performed to explore the effect of exogenous infusions of atrial natriuretic peptide (ANP) on the early inflammatory response during acute sodium overload in normal rats. <i>Methods:<\/i> Sprague Dawley rats were exposed to acute sodium overload (Na 1.5 <i>M<\/i>). Nonhypotensive doses of ANP (1 and 5 \u00b5g \u00b7kg<sup>\u20131<\/sup> \u00b7h<sup>\u20131<\/sup>) were infused simultaneously with sodium or after sodium infusion in order to evaluate prevention or reversion of the inflammatory response, respectively. We determined inflammation markers in renal tissue by immunohistochemistry. <i>Results:<\/i> Creatinine clearance was not reduced in any case. Sodium tubular reabsorption increased after sodium overload (334.3 \u00b1 18.7 vs. control 209.6 \u00b1 27.0 mEq\u00b7min<sup>\u20131<\/sup>, p < 0.05) without changes in mean arterial pressure. This increase was prevented (228.9 \u00b1 26.4; p < 0.05) and reversed (231.5 \u00b1 13.9; p < 0.05) by ANP-5 \u00b5g \u00b7kg<sup>\u20131<\/sup> \u00b7h<sup>\u20131<\/sup>. Sodium overload increased the expression of: RANTES (38.4.3 \u00b1 0.8 vs. 2.9 \u00b1 0.6%, p < 0.001), transforming-growth-factor-\u03b2<sub>1<\/sub> (35.3 \u00b1 1.0 vs. 5.0 \u00b1 0.7%, p < 0.001), \u03b1-smooth muscle actin (15.6 \u00b1 0.7 vs. 3.1 \u00b1 0.3%, p < 0.001), NF-\u0138B (9.4 \u00b1 1.3 to 2.2 \u00b1 0.5 cells\/mm<sup>2<\/sup>, p < 0.001), HIF-1\u03b1 (38.2 \u00b1 1.7 to 8.4 \u00b1 0.8 cells\/mm<sup>2<\/sup>, p < 0.001) and angiotensin II (35.9 \u00b1 1.3 to 8.2 \u00b1 0.5%, p < 0.001). ANP-5 \u00b5g \u00b7kg<sup>\u20131<\/sup> \u00b7h<sup>\u20131<\/sup> prevented and reversed inflammation: RANTES (9.2 \u00b1 0.5 and 6.9 \u00b1 0.7, p < 0.001); transforming growth factor-\u03b2<sub>1<\/sub> (13.2 \u00b1 0.7 and 10.2 \u00b1 0.5, p < 0.001) and \u03b1-smooth muscle actin (4.1 \u00b1 0.4 and 5.2 \u00b1 0.4, p < 0.001). Both prevention and reversion by ANP were associated with downregulation of NF-\u0138B (3.2 \u00b1 0.4 and 2.8 \u00b1 0.5, p < 0.001) and angiotensin II (8.2 \u00b1 0.5 and 9.1 \u00b1 0.7, p < 0.001) and diminished hypoxia evaluated through HIF-1\u03b1 expression (8.4 \u00b1 0.8 and 8.8 \u00b1 0.7, p < 0.001). <i>Conclusion:<\/i> Our study provides evidence supporting a protective role of ANP in both prevention and reversion of renal inflammation in rats with acute sodium overload.<\/jats:p>","DOI":"10.1159\/000098148","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T23:18:32Z","timestamp":1166829512000},"page":"590-601","source":"Crossref","is-referenced-by-count":19,"title":["Renal Protective Role of Atrial Natriuretic Peptide in Acute Sodium Overload-Induced Inflammatory Response"],"prefix":"10.1159","volume":"26","author":[{"given":"Mar\u00eda In\u00e9s","family":"Ros\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge E.","family":"Toblli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana L.","family":"Della Penna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Gorzalczany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Pandolfo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Cavallero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belisario E.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M400461200"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000092792.97122.E0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199503093321006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00220.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mnh.0000196148.42460.4f"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1357-2725%2802%2900271-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000155305.49439.4C"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000081793"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.peptides.2004.09.024"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2174%2F1568016052773333"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.peptides.2004.08.030"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-291X%2802%2900807-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.peptides.2004.08.034"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000020623"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001831"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1748-1716.1961.tb02147.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2F314264a0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1042%2FBJ20021087"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0955-0674%2800%2900194-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.50"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.febslet.2005.03.088"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.62.s82.4.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00476.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000017068.58856.F3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.143.3.846"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.22.13444"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1152%2Fajplung.00294.2004"}],"container-title":["American 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