{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:51Z","timestamp":1790281791621,"version":"4.1.0"},"reference-count":44,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To determine the involvement of oxidative stress in the salivary gland of patients with Sj\u00f6gren\u2019s syndrome (SS). &lt;i&gt;Methods:&lt;\/i&gt; Oxidative damage to the gland was measured by 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) and hexanoyl-lysine (HEL) using the SS saliva. In addition, lactate dehydrogenase (LDH) and mitochondrial glutamic-oxaloacetic transaminase (m-GOT), both general markers for cell damage, were also analyzed. &lt;i&gt;Results:&lt;\/i&gt; Increased levels of 8-OHdG and HEL were found in the saliva of SS patients, but not in that of patients with other salivary gland dysfunction or of healthy individuals. Levels of LDH and m-GOT were significantly correlated with 8-OHdG and HEL levels, respectively. Furthermore, the increased levels of 8-OHdG and HEL were also correlated in the SS saliva. &lt;i&gt;Conclusion:&lt;\/i&gt; These findings suggested the involvement of oxidative stress in glandular tissue destruction in SS. It was indicated that the detection of 8-OHdG and HEL in the saliva may become a useful tool for the diagnosis of SS.<\/jats:p>","DOI":"10.1159\/000098211","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:39:11Z","timestamp":1172065151000},"page":"252-260","source":"Crossref","is-referenced-by-count":106,"title":["Possible Involvement of Oxidative Stress in Salivary Gland of Patients with Sj\u00f6gren\u2019s 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