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The goal of this study was to analyze electrophysiological, motor, cognitive and behavioral changes produced by caffeine ingestion after sleep deprivation. Ten subjects were evaluated after sleep deprivation, comparing the ingestion of either 400 mg of caffeine or placebo, in a double-blind randomized study. The variables analyzed were: quantitative EEG, the event-related potential (ERP-P300) and cognitive responses. The most significant quantitative EEG results, which were characterized by moment \u00d7 treatment interactions, were seen in \u03b1 and &amp;#920; relative power variables. A significant decrease in relative \u03b1 and &amp;#920; was observed in the caffeine group after sleep deprivation. 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