{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:39:22Z","timestamp":1773308362003,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T00:00:00Z","timestamp":1167350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T00:00:00Z","timestamp":1167350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Objective:<\/i> The aim of this study was determination and comparative analysis of the maternal and umbilical cord sCD40L serum levels in pregnancies complicated by pre-eclampsia with and without intrauterine growth retardation (IUGR) and in normotensive pregnancies. <i>Patients and Methods:<\/i> The study was carried out on 16 patients with singleton pregnancies complicated by severe pre-eclampsia with appropriate-for-gestational-age weight infants and 14 pregnant patients with severe pre-eclampsia complicated by IUGR. The control group consisted of 13 healthy normotensive delivering patients. Five milliliters of blood were taken by venipuncture from each pre-eclamptic patient and from each woman from the control group before active phase of labor and 5 ml of umbilical vein blood were taken immediately after delivery and collected in sterile tubes. Maternal and umbilical serum sCD40L concentrations were estimated using a sandwich ELISA assay. <i>Results and Conclusions:<\/i> Our results reveal the higher levels of maternal and umbilical sCD40L serum levels in pregnancy complicated by pre-eclampsia with and without IUGR. The mean maternal values were 4.022 \u00b1 2.399 ng\/ml in group P, 3.914 \u00b1 2.824 ng\/ml in group PI and 0.885 \u00b1 0.064 ng\/ml in healthy controls. The mean umbilical values were 2.633 \u00b1 1.984 ng\/ml in group P, 2.703 \u00b1 1.996 ng\/ml in group PI and 1.112 \u00b1 0.436 ng\/ml in the control group. It seems that these higher concentrations of sCD40L protect maternal immune cells bearing CD40 receptor from Fas-mediated apoptosis. Our findings may suggest also enhanced platelet activation in pre-eclamptic patients. It may be one of the factors responsible for the enhanced procoagulatory and proinflammatory properties, and increased cytokine production, and endothelial cell dysfunction in pregnancies complicated by pre-eclampsia.<\/jats:p>","DOI":"10.1159\/000098316","type":"journal-article","created":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T15:28:38Z","timestamp":1167406118000},"page":"8-13","source":"Crossref","is-referenced-by-count":11,"title":["sCD40 Ligand Determined in Maternal and Umbilical Cord Blood in Pregnancies Complicated by Pre-Eclampsia with and without Intrauterine Growth Retardation"],"prefix":"10.1159","volume":"64","author":[{"given":"Marzena","family":"Laskowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Laskowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Leszczy\u0144ska-Gorzelak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Oleszczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006%2Fsmim.1998.0145"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.182.1.33"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2896%2910060-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830250335"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2F365340a0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2F35393"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1998.00522.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199905%2942%3A5%3C871%3A%3AAID-ANR5%3E3.0.CO%3B2-J"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117453"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.16.8789"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2800%2901227-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.9.3173"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.10.1435"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000070111.98158.6C"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000074030.98009.FF"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2899%2970239-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-2243%2893%2990034-A"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080%2F14767050600798267"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-0378%2802%2900008-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.13.6930"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000028962.04520.01"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0302-247"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830250442"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830250152"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000072704"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:14Z","timestamp":1745461814000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000098316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,29]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000098316","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,29]]}}}