{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:16:04Z","timestamp":1781327764357,"version":"3.54.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T00:00:00Z","timestamp":1167350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T00:00:00Z","timestamp":1167350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> An underlying extracellular matrix defect is suspected in patients with spontaneous cervical artery dissection (SCAD). We test the hypothesis that levels of matrix metalloproteinase (MMP) 2 and 9, and elastase, extracellular-matrix-regulating enzymes involved in the vascular wall remodeling process, are modified in SCAD. <i>Methods:<\/i> The authors prospectively and consecutively recruited 47 patients with SCAD and 52 patients with an ischemic stroke from another cause in 2 centers, and measured their plasmatic level of MMP-2, MMP-9 and elastase 3 months after the vascular event. <i>Results:<\/i> Patients with SCAD had a higher mean MMP-2 level compared with controls [379.2 (SD = 76.6) vs. 355.9 (75.1) ng\/ml; p = 0.11] and had more frequently a high level of MMP-2 (>326 ng\/ml) than controls (77.8 vs. 54.5%, p = 0.019). This association was stronger in patients with multiple dissection than single artery dissection or controls (84.6, 75.0 and 54.5%, respectively, p = 0.018). The levels of MMP-9 and elastase were similar in cases and controls, but more patients had a high level of these enzymes in the group with multiple dissections than in the group with single artery dissection or controls. <i>Conclusion:<\/i> Patients with SCAD have higher plasma levels of proteases, particularly MMP-2. The association is stronger in patients with multiple dissections.<\/jats:p>","DOI":"10.1159\/000098331","type":"journal-article","created":{"date-parts":[[2006,12,29]],"date-time":"2006-12-29T15:28:38Z","timestamp":1167406118000},"page":"299-303","source":"Crossref","is-referenced-by-count":16,"title":["Do Extracellular-Matrix-Regulating Enzymes Play a Role in Cervical Artery Dissection?"],"prefix":"10.1159","volume":"23","author":[{"given":"Beno\u00eet","family":"Guillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Peynet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Benslamia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tzourio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,12,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199405193302008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000087197"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1227%2F00006123-199507000-00008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199709000-00027"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.30.12.2612"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200215334"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2901909-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200103223441206"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000169919.73219.30"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000159739.24607.98"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1992.76.1.0062"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000085085.20390.A3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1999.tb07687.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000078309.56307.5C"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:28Z","timestamp":1745461828000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000098331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,29]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000098331","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,29]]}}}