{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:19Z","timestamp":1791821479356,"version":"4.3.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Objective:<\/i> The aim of this study was to investigate the incidence and long-term outcome of halitosis before and after eradication therapy in patients with functional dyspepsia and <i>Helicobacter pylori<\/i> infection. <i>Subjects and Methods:<\/i> Halitosis and dyspepsia-related symptoms were investigated by way of a questionnaire. Only patients with functional dyspepsia, <i>H. pylori<\/i> infection and no histological evidence of atrophy were included in the study. A total of 18 patients fulfilled these criteria and completed the study. Four to six weeks after the end of eradication treatment, endoscopy or [<sup>13<\/sup>C] breath test was performed to check for <i>H. pylori<\/i> in the gastric mucosa. Halitosis and dyspeptic symptoms were re-evaluated during and at the end of follow-up. <i>Results:<\/i><i>H. pylori<\/i> infection was eradicated in all patients, in the 14\/18 patients (77.8%) with triple drug therapy, and the 4\/18 patients (22.2%) with quadruple drug therapy. During the follow-up period (mean 55.8 \u00b1 21.3 months (range 6\u2013108 months)) resolution of halitosis was observed in 16\/18 patients (88.9%), while 2 patients (11.1%) (p < 0.001) continued to present with halitosis. Also, eradication therapy resulted in statistically significant relief of all dyspeptic symptoms, except bloating. <i>Conclusion:<\/i> Eradication of <i>H. pylori<\/i> in patients with functional dyspepsia and halitosis results in sustained resolution of halitosis during long-term follow-up in the majority of cases. This finding supports the existence of a link between <i>H. pylori<\/i> infection and halitosis and suggests that <i>H. pylori<\/i> eradication might be considered in patients with halitosis.<\/jats:p>","DOI":"10.1159\/000098364","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T17:26:36Z","timestamp":1171473996000},"page":"119-123","source":"Crossref","is-referenced-by-count":34,"title":["Eradication Therapy in <i>Helicobacter pylori<\/i>-Positive Patients with Halitosis: Long-Term Outcome"],"prefix":"10.1159","volume":"16","author":[{"given":"Panagiotis","family":"Katsinelos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Tziomalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigoris","family":"Chatzimavroudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Themistoklis","family":"Vasiliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taxiarchis","family":"Katsinelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Pilpilidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Triantafillidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Paroutoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basilis","family":"Papaziogas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.294.6566.200"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-199210000-00013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-199304000-00031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1026619831442"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0953-6205%2802%2900206-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9969%2871%2990062-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02561692"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1079-2104%2896%2980017-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2895%2992147-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197707212970303"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199910073411502"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199812243392602"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199812243392601"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:53Z","timestamp":1745461853000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000098364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000098364","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}