{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:33Z","timestamp":1745470653545,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Aims:<\/i> Metyrapone causes a decrease in the serum cortisol level without affecting ACTH production in ectopic tumors. We report a case who presented with Cushing\u2019s syndrome due to an ectopic ACTH-producing thymic carcinoid. In the present case, it was demonstrated that metyrapone administration resulted in a significant decrease in the plasma ACTH and serum cortisol levels. We hypothesized that the steroid hormone may promote <i>proopiomelanocortin (POMC) <\/i>gene expression in the carcinoid cells. <i>Methods:<\/i> An 11-year-old boy presented with Cushing\u2019s syndrome. Prior to the detection of a thymic tumor, metyrapone was administered to ameliorate the symptoms of Cushing\u2019s syndrome. Interestingly, plasma ACTH as well as serum cortisol levels immediately decreased after metyrapone administration. The levels of cortisol and ACTH were observed to be normal after complete surgical resection of the tumor. Biological characterization of the tumor cells was by in vitro analysis. <i>Results:<\/i> Thein vitro culture of the tumor cells showed an increased expression of <i>POMC<\/i> in the presence of cortisol. A CpG methylation assay showed that the demethylation of the <i>POMC<\/i> promoter was induced by a steroid hormone. <i>Conclusion:<\/i> These findings suggest that the ectopic ACTH-producing tumor may partly be regulated by the elevated levels of cortisol.<\/jats:p>","DOI":"10.1159\/000098548","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T12:21:57Z","timestamp":1168604517000},"page":"257-262","source":"Crossref","is-referenced-by-count":7,"title":["Steroid-Dependent ACTH-Produced Thymic Carcinoid: Regulation of <i>POMC<\/i> Gene Expression by Cortisol via Methylation of Its Promoter Region"],"prefix":"10.1159","volume":"67","author":[{"given":"Yoko","family":"Mizoguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyuki","family":"Kajiume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichiro","family":"Miyagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8529%2801%2900025-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819930101%2971%3A1%3C106%3A%3AAID-CNCR2820710117%3E3.0.CO%3B2-U"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197204%2929%3A4%3C1061%3A%3AAID-CNCR2820290456%3E3.0.CO%3B2-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2003.10.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.1.05963"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.12.4771"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1981.tb00638.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1310221"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F20.8.1974"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.10.10.1284"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2801%2900282-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1202635"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:32:26Z","timestamp":1745461946000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000098548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000098548","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2007]]}}}