{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:23:44Z","timestamp":1775856224312,"version":"3.50.1"},"reference-count":36,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Seborrheic dermatitis is considered to be a &lt;i&gt;Malassezia&lt;\/i&gt;-driven disease. Little objective information is available so far from biometrological quantitative assessments of this skin condition. Pramiconazole is a novel triazole with potent in vitro antifungal activity, especially against &lt;i&gt;Malassezia&lt;\/i&gt; spp. &lt;i&gt;Objective:&lt;\/i&gt; To study the sequential effects of pramiconazole on &lt;i&gt;Malassezia&lt;\/i&gt;, inflammation and epidermal changes. &lt;i&gt;Method:&lt;\/i&gt;This study was performed in 2 groups of subjects suffering from seborrheic dermatitis. The first group (n = 17) remained untreated and was used as control. Clinical, mycological and biometrological assessments were performed at inclusion and during the following 2 weeks. The second group of subjects (n = 10) received a single 200-mg oral dose of pramiconazole at inclusion. Clinical, mycological and biometrological evaluations were performed before and during 1 month following the single antifungal intake. For both parts of the study, several parameters were assessed including yeast density, desquamation, erythema, itching and sebum excretion. &lt;i&gt;Results:&lt;\/i&gt; In the control group, no significant changes were observed in any of the parameters during the observation period. The findings were markedly different in the pramiconazole-treated subjects. The yeast density was significantly improved on days 3, 7 and 28. Desquamation, erythema, itching, and the global clinical evaluation as assessed by the patients and investigators became significantly improved on days 7 and 28. A trend in decrease of scaliness was noted. No effect on sebum excretion was evidenced. In conclusion, a single 200-mg dose of pramiconazole exhibitsin vivo efficacy in controlling some important clinical aspects of seborrheic dermatitis. Following a reduction in the number of yeasts on day 3, a decrease in the severity of clinical signs and symptoms occurred from day 7 onwards. Sebum excretion appeared uninvolved in the clearing process of seborrheic dermatitis. &lt;i&gt;Conclusion:&lt;\/i&gt; A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis. The density in &lt;i&gt;Malassezia&lt;\/i&gt; present on lesional skin is first decreased, followed by clearing of the clinical signs.<\/jats:p>","DOI":"10.1159\/000098577","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:22:25Z","timestamp":1492550545000},"page":"162-169","source":"Crossref","is-referenced-by-count":26,"title":["A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral Anti-&lt;i&gt;Malassezia&lt;\/i&gt; Agent"],"prefix":"10.1159","volume":"214","author":[{"given":"G\u00e9rald 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