{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:09:51Z","timestamp":1770970191013,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T00:00:00Z","timestamp":1137456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T00:00:00Z","timestamp":1137456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas. &lt;i&gt;Methods:&lt;\/i&gt; Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis. &lt;i&gt;Results:&lt;\/i&gt; Eleven genes presented more than two-fold alteration in expression levels: undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor \u03b2 receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-\u03b1 V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin). &lt;i&gt;Conclusions:&lt;\/i&gt; We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.<\/jats:p>","DOI":"10.1159\/000098708","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T10:15:49Z","timestamp":1169028949000},"page":"161-168","source":"Crossref","is-referenced-by-count":13,"title":["The Changes in Angiogenic Gene Expression in Recurrent Multiple Chorioangiomas"],"prefix":"10.1159","volume":"22","author":[{"given":"Denis","family":"Gallot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffroy","family":"Marceau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Laurichesse-Delmas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Vanlieferinghen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre J.","family":"Dechelotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Lemery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2896%2970427-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.2003.023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000264430"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2803%2900576-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.2000.00299.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F15513819209023296"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddg067"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.2000.00127.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs100249900122"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109%2F00313028809085204"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1201-365"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00292-002-0560-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.10028"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0012-1606%2803%2900449-4"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/98708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:12Z","timestamp":1745462052000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000098708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,17]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000098708","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,17]]}}}