{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:17:06Z","timestamp":1790399826331,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. <i>Methods:<\/i> Timothy grass pollen was exposed to ozone (O<sub>3<\/sub>), nitrogen dioxide (NO<sub>2<\/sub>) and sulphur dioxide (SO<sub>2<\/sub>) alone or in combination. Allergen contents were analysed by 2-dimensional immunoblot using grass pollen-sensitive patient sera. <i>Results:<\/i> For O<sub>3<\/sub>-treated pollen, immunoblotting showed an acidification of allergens Phl p 1b, Phl p 4, Phl p 5 and Phl p 6 and an IgE recognition decrease in Phl p 1, Phl p 2, Phl p 6 and Phl p 13. NO<sub>2<\/sub> exposure induced a decrease in Phl p 2, Phl p 5b and Phl p 6 recognition, and SO<sub>2<\/sub> treatment induced a decrease in Phl p 2, Phl p 6 and Phl p 13 recognition. Moreover, samples treated with a mix of NO<sub>2<\/sub>\/O<sub>3<\/sub> or NO<sub>2<\/sub>\/SO<sub>2<\/sub> showed a higher decrease in allergen content, compared with samples treated with only one pollutant. The O<sub>3<\/sub> acidification was also observed with the NO<sub>2<\/sub>\/O<sub>3<\/sub> mix. <i>Conclusion:<\/i> Exposure of pollen to gaseous pollutants induced a decrease in allergen detection in pollen extracts. This decrease could be due to a mechanical loss of allergens from the altered pollen grains and\/or post-translational modifications affecting allergen recognition by IgE.<\/jats:p>","DOI":"10.1159\/000099079","type":"journal-article","created":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T13:22:43Z","timestamp":1170076963000},"page":"127-134","source":"Crossref","is-referenced-by-count":63,"title":["Modifications of <i>Phleum pratense<\/i> Grass Pollen Allergens following Artificial Exposure to Gaseous Air Pollutants (O<sub>3<\/sub>, NO<sub>2<\/sub>, SO<sub>2<\/sub>)"],"prefix":"10.1159","volume":"143","author":[{"given":"F.","family":"Rogerieux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Godfrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"S\u00e9n\u00e9chal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marli\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Peltre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lacroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.57.s72.5.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-7915%2801%2900282-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.03.00041103a"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.01.056"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.envres.2004.02.009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Foem.60.11.e15"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.2201013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0300-483X%2800%2900293-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tox.2004.09.016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tox.2004.02.007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000237511"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-7915%2801%2900283-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ecoenv.2003.12.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000091600"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000023953"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.56.6.468"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.01872.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000080039"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1976.9999"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Felps.1150080203"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2980193-X"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0161-5890%2896%2900015-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000069013"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-8502%2896%2900187-5"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1021%2Fes0488737"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.1998.00221.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970538-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2800%2901164-9"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:33Z","timestamp":1745462253000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099079","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}