{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:34:13Z","timestamp":1790127253235,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Previous studies using transesophageal echocardiography (TEE) report an association of valvular heart disease (VHD) with cerebral infarcts and central neuropsychiatric systemic lupus erythematosus (NPSLE). However, TEE cannot be routinely used. <i>Aim:<\/i> To determine if VHD detected by transthoracic echocardiography (TTE) is associated with focal brain injury on magnetic resonance imaging (MRI) and secondarily with central NPSLE. <i>Methods:<\/i> Sixty-nine patients with systemic lupus erythematosus underwent general clinical, neuropsychiatric and laboratory evaluations followed by MRI of the brain and TTE. <i>Results:<\/i> Forty-one patients (59%) had NPSLE (stroke, transient ischemic attack, cognitive dysfunction, acute confusional state, seizures or psychosis); 46 (67%) had focal brain injury on MRI (cerebral infarcts, white matter lesions or small punctate lesions); 38 (55%) had VHD (vegetations, thickening or regurgitation). VHD was more common in patients with than in those without focal brain injury and NPSLE (all p < 0.05); focal brain lesions were more common in patients with than in those without NPSLE (all p < 0.04); and VHD was an independent predictor of focal brain lesions and NPSLE (both p < 0.04). <i>Conclusion:<\/i> In patients with systemic lupus erythematosus, VHD detected by TTE is associated with focal brain injury and NPSLE.<\/jats:p>","DOI":"10.1159\/000099104","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T16:55:23Z","timestamp":1171299323000},"page":"331-337","source":"Crossref","is-referenced-by-count":31,"title":["Valvular Heart Disease by Transthoracic Echocardiography Is Associated with Focal Brain Injury and Central Neuropsychiatric Systemic Lupus Erythematosus"],"prefix":"10.1159","volume":"108","author":[{"given":"Carlos A.","family":"Roldan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika A.","family":"Gelgand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Qualls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmer L.","family":"Sibbitt Jr.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2005.02.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.rhu.0000200378.42836.7f"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199611073351903"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780251101"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780400928"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780350606"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780390303"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199904%2942%3A4%3C599%3A%3AAID-ANR2%3E3.0.CO%3B2-F"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00005053-198602000-00002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00234-003-1049-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0894-7317%2803%2900335-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0049-0172%2805%2980012-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199801%2941%3A1%3C41%3A%3AAID-ART6%3E3.0.CO%3B2-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1191%2F0961203303lu468oa"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410230411"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2004.032813"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0049-0172%2879%2980009-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.46.1.37"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000174866"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000047970"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1999.tb07364.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa035471"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:47Z","timestamp":1745462267000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099104","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}