{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:32:44Z","timestamp":1773837164588,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; We evaluated the efficacy and safety of long-term management of patients with vernal keratoconjunctivitis (VKC) with bromfenac sodium eye drops in combination with corticosteroids and anti-allergic eye drops. &lt;i&gt;Methods:&lt;\/i&gt; Twenty-two patients with VKC were randomly assigned to receive two test eye drops, either bromfenac sodium 0.1% (group A) or placebo eye drops (normal saline; group B) for a mean observation period of 20.9 months. Topical corticosteroids and mast cell stabilizers were continued during the observation period. &lt;i&gt;Results:&lt;\/i&gt; The mean 2-year recurrence rate was 90.9% in group A and 11.3% in group B, with a significant difference. No serious side effect was observed in group A. &lt;i&gt;Conclusion:&lt;\/i&gt; These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC.<\/jats:p>","DOI":"10.1159\/000099294","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T10:15:22Z","timestamp":1176891322000},"page":"153-158","source":"Crossref","is-referenced-by-count":14,"title":["Topical Bromfenac Sodium for Long-Term Management of Vernal Keratoconjunctivitis"],"prefix":"10.1159","volume":"221","author":[{"given":"Eiichi","family":"Uchio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Kadonosono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900092-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00004397-198802840-00009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1995.tb04250.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.82.1.82"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.1995.tb03796.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.1999.00501.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1995.tb04254.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.1978.tb05690.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000024055"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.78.5.365"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.1991.tb02000.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089%2Fjop.1995.11.361"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1089%2Fjop.1998.14.137"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1054538"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00055735-199808000-00010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-001-0051-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00417-002-0612-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10384-004-0127-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000074074"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01964911"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-71-1-235"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01664932"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01093.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.18364"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ico.0000177835.93130.d4"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:23Z","timestamp":1745462363000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099294","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}