{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:14:42Z","timestamp":1775060082973,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; Primary ocular natural killer\/T-cell lymphoma (NKTL) is rare. This study aims to characterize the clinical manifestations, diagnosis and treatment methods of primary ocular NKTL. &lt;i&gt;Methods:&lt;\/i&gt; Clinical data of seven patients with ocular NKTL from 1982 to 2004 were collected. A morphologic, immunohistochemical and molecular analysis was undertaken. &lt;i&gt;Results:&lt;\/i&gt; Clinical manifestations and computed tomography of the patients were typical. LCA CD56 CD3&amp;#917; Ki-67 granzyme B (GrB) and T-cell intracellular antigen-1(TIA-1) were mostly positive. Clonal T-cell-receptor gene rearrangements of five patients showed negative findings, and the detection of Epstein-Barr virus showed positive. All patients died 5 months to 28 months after presentation. &lt;i&gt;Conclusion:&lt;\/i&gt; Ocular NKTL is a highly aggressive clinical course with poor prognosis. The diagnosis relies on clinicopathologic findings.<\/jats:p>","DOI":"10.1159\/000099297","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T10:15:22Z","timestamp":1176891322000},"page":"173-179","source":"Crossref","is-referenced-by-count":15,"title":["Primary Ocular Natural Killer\/T-Cell Lymphomas: Clinicopathologic Features and Diagnosis"],"prefix":"10.1159","volume":"221","author":[{"given":"Yuli","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819860701%2958%3A1%3C67%3A%3AAID-CNCR2820580113%3E3.0.CO%3B2-F"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-1069%28199705%2915%3A2%3C71%3A%3AAID-HON601%3E3.0.CO%3B2-U"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fhupa.2003.33"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.10332"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-9071.2001.d01-18.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2899%2990492-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.09.036"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0385-8146%2800%2900069-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199911000-00006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199601000-00012"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199409000-00009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199304000-00010"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fhupa.2003.33"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:24Z","timestamp":1745462364000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099297","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}