{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:14:08Z","timestamp":1774973648595,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; To evaluate the ability of GDx with variable corneal compensator (VCC) compared to visual-evoked potentials (VEPs) and standard automated perimetry (SAP) in the detection of early optic nerve damage in patients with multiple sclerosis (MS). &lt;i&gt;Methods:&lt;\/i&gt; 46 eyes of 23 MS patients were included. Ten of them had a history of acute retrobulbar optic neuritis. A control group of 20 normal subjects was also included. All subjects underwent a complete ophthalmological examination and testing with SAP, GDx VCC and VEPs. &lt;i&gt;Results:&lt;\/i&gt; 19 eyes (41.3%) were abnormal with GDx VCC compared to 38 eyes (82.6%) with SAP and 31 (64.4%) with VEPs. In the optic neuritis group, 9 eyes (69.2%) had optic nerve pallor; SAP was abnormal in 8 of these eyes (61.5%) while VEPs and GDx VCC were abnormal in 6 eyes (46.1%). 2\/20 eyes (10.0%) in the control group gave a false-positive abnormal result with SAP. GDx VCC and VEP were normal for all the eyes in the control group. &lt;i&gt;Conclusions:&lt;\/i&gt; GDx VCC is less able to detect early defects in MS patients compared to the currently used standard techniques of SAP and VEPs.<\/jats:p>","DOI":"10.1159\/000099299","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T10:15:22Z","timestamp":1176891322000},"page":"186-189","source":"Crossref","is-referenced-by-count":20,"title":["Nerve Fibre Layer Analysis with GDx with a Variable Corneal Compensator in Patients with Multiple Sclerosis"],"prefix":"10.1159","volume":"221","author":[{"given":"Giovanni","family":"Della Mea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Bacchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zeppieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Brusini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Cutuli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Luigi","family":"Gigli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004150170029"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00155090"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410270406"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109%2F01658108309009732"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.03-1213"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2899%2990075-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.85.5.586"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.64.4.505"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.121.4.484"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.86.3.285"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20575"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2005.10.040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.03-0692"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.03-0646"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:25Z","timestamp":1745462365000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099299","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}