{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:39:03Z","timestamp":1767983943228,"version":"3.49.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Excessive release of proinflammatory cytokines by activated microglia surrounding senile plaques might contribute to the neurodegeneration associated with Alzheimer\u2019s disease (AD). Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes, like interleukin 1 (IL-1). As PARP-1 overactivity has been shown in the AD brain, we tested the hypothesis that the PARP-1 \u2013410 and \u20131672 polymorphisms would predispose people to AD due to overexpression of the PARP-1 gene, independently or in concert with the proinflammatory IL-1A \u2013889 polymorphism. So, we performed a case-control study in 263 Spanish AD patients and 293 healthy controls. PARP-1 \u2013410 and PARP-1 \u20131672 haplotypes were associated with an increased risk for AD (global haplotype association p value = 0.019), and, in addition, PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A \u2013889 allele 2.<\/jats:p>","DOI":"10.1159\/000099471","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T11:25:42Z","timestamp":1171020342000},"page":"215-218","source":"Crossref","is-referenced-by-count":38,"title":["Interaction between Poly(ADP-Ribose) Polymerase 1 and Interleukin 1A Genes Is Associated with Alzheimer\u2019s Disease Risk"],"prefix":"10.1159","volume":"23","author":[{"given":"Jon","family":"Infante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Mateo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloy","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coro","family":"S\u00e1nchez-Quintana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascual","family":"S\u00e1nchez-Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Fern\u00e1ndez-Viadero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Berciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onofre","family":"Combarros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0896-6273%2802%2900794-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.2003.01684.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F122.2.247"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00018-004-4509-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-002-0819-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fbioinformatics%2Fbtl268"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000073735"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.10864"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-313X.2005.00521.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0306895101"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.030866"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:41:10Z","timestamp":1745462470000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099471","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}