{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:13:06Z","timestamp":1777947186098,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[1992,2,25]],"date-time":"1992-02-25T00:00:00Z","timestamp":698976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[1992,2,25]],"date-time":"1992-02-25T00:00:00Z","timestamp":698976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"abstract":"<jats:p>Fifty patients with meningiomas were treated during the initial 30 months experience using the 201 source cobalt-60 gamma knife at the University of Pittsburgh. The most frequent site of origin was the skull base. Stereotactic radiosurgery was the primary treatment modality in 16 (32%) patients with symptomatic tumors demonstrated by neuroimaging; Thirty-six patients (72%) had undergone at least one craniotomy, and 4 patients (8%) previously had fractionated external beam radiation therapy. The proximity of cranial nerves, vascular, pituitary and brainstem structures to the often convoluted tumor mass was crucial to dose selection. Follow-up imaging studies and clinical analysis of patients were performed at 6-month intervals. The actuarial 2-year tumor control rate was 96%. Only 2 patients have shown delayed tumor growth outside the radiosurgical treatment volume. To date, stereotactic radiosurgery proved to be a relatively safe and effective therapy for selected patients with symptomatic meningiomas, either as an adjuvant treatment to prior resection, or as a primary treatment alternative for patients whose advanced age, medical condition or high-risk tumor location mitigated against surgical resection.<\/jats:p>","DOI":"10.1159\/000099552","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T06:25:42Z","timestamp":1171002342000},"page":"11-21","source":"Crossref","is-referenced-by-count":44,"title":["Gamma Knife Radiosurgery of Meningiomas"],"prefix":"10.1159","author":[{"given":"Douglas","family":"Kondziolka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Dade","family":"Lunsford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Coffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Flickinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1992,2,25]]},"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000099552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:30:22Z","timestamp":1777761022000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000099552","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"value":"1011-6125","type":"print"},{"value":"1423-0372","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2,25]]}}}