{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:40:57Z","timestamp":1791484857816,"version":"4.3.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Vitiligo is a chronic disease that mostly affects children and young adults. Nowadays many treatment options are available; however, most of them have limited efficacy and in most cases would result in undesirable complications. &lt;i&gt;Objective:&lt;\/i&gt; To determine the extent of repigmentation according to the location of the lesions after applying topical cream pimecrolimus 1% in vitiligo patients. &lt;i&gt;Materials and Methods:&lt;\/i&gt; Thirty consecutive patients with vitiligo lesions affecting less than 20% of body surface area without any previous history of spontaneous repigmentation were treated with pimecrolimus cream 1% twice daily for 12 weeks. The extent of repigmentation in vitiligo lesions was determined in each patient after 6 and 12 weeks. &lt;i&gt;Results:&lt;\/i&gt; Moderate to excellent response (repigmentation &gt;26%) was observed in 6.6 and 25.9% of vitiligo lesions 6 and 12 weeks after treatment, respectively. More responsive lesions were located on the trunk, face and elbow (85.7, 75 and 70%). &lt;i&gt;Conclusion:&lt;\/i&gt; Pimecrolimus cream 1% results in repigmentation in vitiligo in different extents according to the location of the lesion; however, to clearly prove its efficacy as monotherapy or in combination with other available treatment options, double-blind placebo-controlled studies are essential.<\/jats:p>","DOI":"10.1159\/000099592","type":"journal-article","created":{"date-parts":[[2007,3,21]],"date-time":"2007-03-21T13:00:40Z","timestamp":1174482040000},"page":"253-259","source":"Crossref","is-referenced-by-count":25,"title":["Pimecrolimus Cream in Repigmentation of Vitiligo"],"prefix":"10.1159","volume":"214","author":[{"given":"Hassan","family":"Seirafi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Farnaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Firooz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Vasheghani-Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh-Sadaat","family":"Alirezaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya","family":"Dowlati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000073099"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.112.11.1531"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.114594"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.117046"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1988.tb01260.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000084751"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970194-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2165%2F00128071-200607010-00002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.2004.01632.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.05.036"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mop.0000133081.24760.08"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.5.651"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.5.581"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000086739"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-200565040-00002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.293.6.730"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2003.12.031"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1524-4725.2004.30058.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000065863"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.126500"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000065845"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.5.571"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.126250"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0781.2003.00005.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000081479"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080%2F000155502320624113"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:42:33Z","timestamp":1745462553000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099592","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}