{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:15:59Z","timestamp":1768014959893,"version":"3.49.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Acne often results in permanent, badly tolerated, difficult to treat scars. &lt;i&gt;Objective:&lt;\/i&gt; To evaluate the efficacy and safety of a 0.1% retinaldehyde\/6% glycolic acid (RALGA) cream at preventing and treating acne scarring in patients previously treated for moderate acne. &lt;i&gt;Methods:&lt;\/i&gt; A double-blind vehicle-controlled study was conducted in 145 patients randomized to apply RALGAor vehicle cream every evening for 3 months. Global scarring score and patient\u2019s assessment of global efficacy, then residual acne lesions, quality of life and tolerance were evaluated at inclusion and each month until study completion. &lt;i&gt;Results:&lt;\/i&gt; Global scarring score, number of inflammatory lesions and comedones significantly improved in each group from day 28 (p &lt; 0.0001). Number of inflammatory lesions were significantly decreased only in the RALGA group. RALGA cream was more efficient than vehicle on scarring after 3 months in compliant patients (p = 0.007) due to erythema and hyperpigmentation improvement. &lt;i&gt;Conclusion:&lt;\/i&gt; RALGA cream is efficient at preventing and treating acne scarring in patients with moderate acne.<\/jats:p>","DOI":"10.1159\/000099593","type":"journal-article","created":{"date-parts":[[2007,3,21]],"date-time":"2007-03-21T13:00:40Z","timestamp":1174482040000},"page":"260-267","source":"Crossref","is-referenced-by-count":14,"title":["Combined 0.1% Retinaldehyde\/ 6% Glycolic Acid Cream in Prophylaxis and Treatment of Acne Scarring"],"prefix":"10.1159","volume":"214","author":[{"given":"Brigitte","family":"Dreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Katsambas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Pelfini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Plantier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Jancovici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Ribet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9r\u00e8se","family":"Nocera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Morinet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Khammari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2165%2F00128071-200102030-00002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-0960.2001.00487.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1994.tb01200.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.292.6.726"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2896%2990443-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000051382"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.1999.00499.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000081498"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.1999.tb01000.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2884%2980466-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.2000.00076.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000081501"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000081503"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1992.tb02521.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1994.tb01167.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1087-0024.2004.09113.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000076481"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2004.03.001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-199753030-00003"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.113451"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:42:34Z","timestamp":1745462554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099593","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}