{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:51:42Z","timestamp":1789962702404,"version":"4.0.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> A polymorphism locating at position 73 of cystatin C <i>(CST3)<\/i> exon 1 was suggested to be associated with Alzheimer disease (AD), but with contradictory results. The relationship between the <i>CST3<\/i> genotype and the cystatin C plasma level in AD remains unknown. <i>Objective:<\/i> We aim to determine the association between <i>CST3<\/i> polymorphism and the plasma levels of cystatin C in AD and nondemented control individuals. <i>Method:<\/i> The polymorphisms of the <i>CST3<\/i> genotype were determined using PCR followed by restriction fragment length polymorphism analysis, and the plasma cystatin C concentrations were quantified by sandwich ELISA in 175 AD and 461 control subjects. <i>Results:<\/i> Although the <i>CST3A<\/i> allele frequencies were similar between the two groups, the <i>CST3A\/A <\/i>homozygote was significantly associated with late-onset AD. As expected, the established AD genetic risk factor <i>APOE <\/i>&#917;<i>4<\/i> allele was overrepresented in the AD cohort. The plasma cystatin C levels were lower in the AD patients than in the control group. Furthermore, plasma cystatin C levels were associated positively with age and negatively with <i>CST3A<\/i> allele in the control group. <i>Conclusion:<\/i> The homozygous <i>CST3A\/A<\/i> genotype confers a risk for AD in Taiwan Chinese. Such an association may be due to the reduced level of cystatin C in the peripheral circulation.<\/jats:p>","DOI":"10.1159\/000100021","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T13:39:11Z","timestamp":1172065151000},"page":"251-257","source":"Crossref","is-referenced-by-count":38,"title":["Genotype and Plasma Concentration of Cystatin C in Patients with Late-Onset Alzheimer Disease"],"prefix":"10.1159","volume":"23","author":[{"given":"Liang-Jen","family":"Chuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne H.H.","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chyi","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Min","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0706-780"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0600549103"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10048-004-0174-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.11.1579"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.79.9.3024"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.83.9.2974"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2003.11.006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fpmic.200300470"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-002-0751-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017%2FS1041610297004870"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2801%2902307-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2005.09.006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2001.141"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinbiochem.2005.05.012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F10408360490504934"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2000.8237"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI7709"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0007-1323.2001.01911.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000014421.15948.67"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020200068"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0047-6374%2801%2900364-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0969-9961%2803%2900012-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000106725"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000080714"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1385%2FJMN%3A22%3A1-2%3A13"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:46:19Z","timestamp":1745462779000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100021","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}