{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:25Z","timestamp":1745470705770,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>The relationship between the apparently random chromosomal changes found in aneuploidy and the genetic instability driving the progression of cancer is not clear. We report a test of the hypothesis that aneuploid chromosomal abnormalities might be selected to preserve cell-survival genes during loss of heterozygosity (LOH) formations which eliminate tumor suppressor genes. The LOHs and structurally abnormal chromosomes present in the aneuploid LoVo (colon), A549 (lung), SUIT-2 (pancreas), and LN-18 (glioma) cancer cell lines were identified by single nucleotide polymorphisms (SNPs) and Spectral Karyotyping (SKY). The Mann-Whitney U and chi square tests were used to evaluate possible differences in chromosome numbers and abnormalities between the cell lines, with two-tailed &lt;i&gt;P&lt;\/i&gt; values of &lt;0.01 being considered significant. The cell lines differed significantly in chromosome numbers and frequency of structurally abnormal chromosomes. The SNP analysis revealed that each cell line contained at least a haploid set of somatic chromosomes, consistent with our hypothesis that cell-survival genes are widely scattered throughout the genome. Further, over 90% of the chromosomal abnormalities seemed to be selected, often after LOH formation, for gene-dosage compensation or to provide heterozygosity for specific chromosomal regions. These results suggest that the chromosomal changes of aneuploidy are not random, but may be selected to provide gene-dosage compensation and\/or retain functional alleles of cell-survival genes during LOH formation.<\/jats:p>","DOI":"10.1159\/000100406","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T12:06:03Z","timestamp":1176465963000},"page":"235-247","source":"Crossref","is-referenced-by-count":4,"title":["A model for genetic complementation controlling the chromosomal abnormalities and loss of heterozygosity formation in cancer"],"prefix":"10.1159","volume":"116","author":[{"given":"A.L.","family":"Nestor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Hollopeter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-I.","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9098%28199803%2967%3A3%3C151%3A%3AAID-JSO2%3E3.0.CO%3B2-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819840415%2953%3A8%3C1708%3A%3AAID-CNCR2820530815%3E3.0.CO%3B2-L"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F32688"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198903093201003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00697180"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2899%2900236-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01655433"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1449"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygeno.2004.07.015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1956.tb32124.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00784356"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2264%28199607%2916%3A3%3C155%3A%3AAID-GCC1%3E3.0.CO%3B2-Y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800750111"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-05-1961"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-198804000-00014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fhumu.10147"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2F386623a0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1956.tb50892.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.88.15.6427"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1956.tb50894.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00335-002-2197-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2802%2900730-6"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000068544"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.959840"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900665-3"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.ge.24.120190.003151"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.26.15121"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819880815%2962%3A4%3C749%3A%3AAID-CNCR2820620418%3E3.0.CO%3B2-W"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:23Z","timestamp":1745463023000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100406","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5104570","asserted-by":"subject"}]},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2007]]}}}