{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:25:06Z","timestamp":1792121106291,"version":"4.4.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Angiogenesis is essential for the development, growth and advancement of solid tumors. Angiogenesis is induced by hypoxia with the angiogenic transcription factor hypoxia-inducible factor (HIF). This prompted us to study the clinical implications of HIF relative to angiogenesis in uterine endometrial cancers. &lt;i&gt;Methods:&lt;\/i&gt; Sixty patients underwent curative resection for uterine endometrial cancers. In the tissue of 60 uterine endometrial cancers, HIF-1\u03b1, HIF-2\u03b1 and HIF-1\u03b2 mRNA levels, and the ratio of angiopoietin (Ang)-2 to Ang-1 (Ang-2\/Ang-1) mRNA levels were determined by RT real-time PCR; histochemical scores and localization of HIF-1\u03b1 were determined by immunohistochemistry. Levels of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and interleukin-8 (IL-8) were determined by enzyme immunoassay. &lt;i&gt;Results:&lt;\/i&gt; In stage I uterine endometrial cancers, HIF-1\u03b1 histochemical scores and mRNA levels significantly increased with myometrial invasion of uterine endometrial cancers. HIF-1\u03b1 histochemical scores and mRNA levels correlated with the levels of Ang-2\/Ang-1 and IL-8. &lt;i&gt;Conclusion:&lt;\/i&gt; The angiogenic mediator HIF-1\u03b1, linked to Angs and IL-8, might work on angiogenesis with myometrial invasion of cancer cells in uterine endometrial cancers.<\/jats:p>","DOI":"10.1159\/000100477","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T21:22:18Z","timestamp":1492550538000},"page":"95-101","source":"Crossref","is-referenced-by-count":9,"title":["Plausible Linkage of Hypoxia-Inducible Factor (HIF) in Uterine Endometrial Cancers"],"prefix":"10.1159","volume":"71","author":[{"given":"Jiro","family":"Fujimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Mahfuzul","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israt","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Toyoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao Li","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Tamaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0065-230X%2808%2960946-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.270.3.1230"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.271.50.32253"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.11.5667"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.9.4273"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.15.8104"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2F28867"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F17.11.3005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fmolehr%2F4.5.509"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2898%2900129-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2898%2900232-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdf078"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0020-7292%2889%2990482-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.92.12.5510"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.11.1.72"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1852076"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2981812-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.277.5322.55"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-2697%2876%2990527-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-03-3566"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.10774"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6690555"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.neo.7900195"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.42.30196"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2899%2900378-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0092-8674%2800%2981813-9"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:51:14Z","timestamp":1745463074000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":26,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100477","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}