{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:28Z","timestamp":1745470708590,"version":"3.40.4"},"reference-count":59,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>Progestin-facilitated lordosis of hamsters and rats is enhanced by activation of dopamine type 1 (D&lt;sub&gt;1&lt;\/sub&gt;) or GABA&lt;sub&gt;A&lt;\/sub&gt;\/benzodiazepine receptor complexes (GBRs) in the ventral tegmental area (VTA) and these effects involve G-proteins and second messengers, such as adenosine 3\u2032,5\u2032-monophosphate (cAMP). We examined whether D&lt;sub&gt;1&lt;\/sub&gt;- and\/or GBR-mediated increases in progestin-facilitated lordosis of female hamsters and rats involve the cAMP-dependent protein kinase, protein kinase A (PKA), in the VTA. In experiment 1, ovariectomized hamsters, primed with estradiol (E&lt;sub&gt;2&lt;\/sub&gt;; 10 \u00b5g at h 0) + progesterone (P; 100 \u00b5g at h 45), were first pre-tested for lordosis and motor behavior (h 48) and then infused with the PKA inhibitor, Rp-cAMP (100 ng\/side), or vehicle. Thirty minutes later, hamsters were retested and then received infusions of the D&lt;sub&gt;1&lt;\/sub&gt; agonist, SKF38393 (100 ng\/side), the GBR agonist, muscimol (100 ng\/side), or vehicle to the VTA. Hamsters were post-tested for lordosis and motor behavior 30 min later. In Experiment 2, ovariectomized rats, primed with E&lt;sub&gt;2&lt;\/sub&gt; (10 \u00b5g at h 0), were first pre-tested for lordosis and then infused with Rp-cAMP (100 ng\/side) or vehicle to the VTA at h 44. Immediately after testing, rats received infusions of SKF38393 (100 ng\/side), muscimol (100 ng\/side), or vehicle and were retested for lordosis. Rats were then infused with the neurosteroid, 5\u03b1-pregnan-3\u03b1-ol-20-one (3\u03b1,5\u03b1-THP; 100 or 200 ng\/side), or \u03b2-cyclodextrin vehicle and were post-tested for lordosis and motor behavior 10 and 60 min later. The enhancing effects of progestins or progestins plus D&lt;sub&gt;1&lt;\/sub&gt; or GBR activation on lordosis of E&lt;sub&gt;2&lt;\/sub&gt;-primed hamsters and rats were blocked by the PKA inhibitor, Rp-cAMP. Thus, in the VTA, progestins\u2019 membrane actions involving D&lt;sub&gt;1&lt;\/sub&gt; or GBRs are mediated, in part, by PKA.<\/jats:p>","DOI":"10.1159\/000100510","type":"journal-article","created":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T12:39:39Z","timestamp":1174048779000},"page":"405-414","source":"Crossref","is-referenced-by-count":8,"title":["In the Ventral Tegmental Area, Progestins\u2019 Membrane-Mediated Actions for Lordosis of Hamsters and Rats Involve Protein Kinase A"],"prefix":"10.1159","volume":"84","author":[{"given":"Sandra M.","family":"Petralia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia A.","family":"Walf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl 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