{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:22:01Z","timestamp":1782231721223,"version":"3.54.5"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>CD4+ CD25+ T cells regulate various kinds of immune-mediated diseases. Here, we sought to clarify whether CD4+ CD25+ T cells also regulate the development of experimental allergic conjunctivitis (EC). Thymectomized BALB\/c mice, treated with anti-CD25 antibody (PC61), normal rat immunoglobulin G (nrIgG) or left untreated were immunized with short ragweed pollen (RW). Ten days later, the mice were challenged with RW in eye drops, and 24 h later, the conjunctivas, blood and spleens were harvested. The severity of EC, as evaluated by conjunctival eosinophil numbers, was significantly higher in the PC61-treated group as compared with the other two groups. The PC61-treated group also had significantly higher RW-specific IgE and IgG1 levels and displayed RW-specific splenocyte proliferation and RW-induced splenocyte T helper cell 2 cytokine production. However, PC61 treatment of unthymectomized mice did not affect the severity of EC. Thus, thymus-derived CD25+ T cells regulate the development of EC. Furthermore, transfer of Foxp3-expressing CD4+ CD25+ T cells from na\u00efve mice into RW-sensitized mice suppressed the development of EC in these mice after RW challenge. Taken together, these results suggest that CD4+ CD25+ T cells regulate the development of EC.<\/jats:p>","DOI":"10.1159\/000100573","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T12:22:03Z","timestamp":1173702123000},"page":"276-281","source":"Crossref","is-referenced-by-count":16,"title":["Thymus-Derived CD4+ CD25+ T Cells Suppress the Development of Murine Allergic Conjunctivitis"],"prefix":"10.1159","volume":"143","author":[{"given":"Tamaki","family":"Sumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuki","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970206-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.86.10.1166"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.02-1323"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F02713680590927560"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exer.2005.06.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-065X.2001.1820102.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20051506"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0105-2896.2005.00250.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F08830180590934976"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2005.10.177"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fnmeth903"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:52:15Z","timestamp":1745463135000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100573","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}