{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:47:28Z","timestamp":1761630448025,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition whose pathogenesis and effect on airways remain unclear. The aim of the study was to evaluate the changes in endothelial-derived mediators following intensive exercise in asthmatic patients. &lt;i&gt;Methods:&lt;\/i&gt; The study was conducted in a group of 25 asthmatic patients (15 with EIB, 10 without EIB) and 8 healthy volunteers. Changes induced by intensive exercise in the plasma concentrations of endothelin-1 (ET-1), thrombomodulin and soluble E-selectin were determined. Moreover, the possible correlations of these measurements with the results of baseline lung function, bronchial hyperreactivity (BHR), exhaled nitric oxide (F&lt;sub&gt;ENO&lt;\/sub&gt;), baseline eosinophil cationic protein, peripheral blood eosinophilia and total IgE were investigated. &lt;i&gt;Results:&lt;\/i&gt; In the group of asthmatics with EIB, statistically significantly higher baseline concentrations of ET-1 and soluble E-selectin compared with asthmatics with negative exercise test results were revealed. In this group of patients, ET-1, thrombomodulin and soluble E-selectin concentrations significantly increased after exercise. Baseline concentrations of ET-1 as well as an increase in soluble E-selectin concentrations 60 min after exercise showed a statistically significant correlation with baseline eosinophil cationic protein, F&lt;sub&gt;ENO&lt;\/sub&gt; and BHR. The increase in plasma concentrations of ET-1 15 min after exercise and soluble E-selectin 60 min after exercise showed a statistically significant correlation with the increase in F&lt;sub&gt;ENO&lt;\/sub&gt; and BHR to histamine 24 h after exercise. &lt;i&gt;Conclusions:&lt;\/i&gt; We suggest that during EIB changes in the function of pulmonary endothelium occur and these changes may influence inflammation of the airway and remodeling in asthmatic patients.<\/jats:p>","DOI":"10.1159\/000100577","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T09:53:04Z","timestamp":1173865984000},"page":"299-310","source":"Crossref","is-referenced-by-count":4,"title":["The Role of Endothelium-Derived Mediators in Exercise-Induced Bronchoconstriction"],"prefix":"10.1159","volume":"143","author":[{"given":"Ziemowit","family":"Zietkowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bodzenta-Lukaszyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Magdalena","family":"Tomasiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Skiepko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Szmitkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Mroczko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.109822"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2884%2990297-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2962977-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.96.09071335"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0838.2004.00383.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089%2F107999099314234"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1843.1999.00214.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2169%2Finternalmedicine.34.158"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2884%2990302-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.122.1.166"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200412-1667OC"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1996.tb32562.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F332411a0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.172.6.1741"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1997.tb00746.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00003246-199706000-00011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2800%2900683-X"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1081%2FJAS-120023579"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200310-1376OC"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1997.tb00684.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2891%2990438-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2893%2990267-O"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000236892"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.39.8.983"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:52:18Z","timestamp":1745463138000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100577","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2007]]}}}