{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:43:16Z","timestamp":1773070996597,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background and Aim:<\/i> Obesity affects cardiovascular risk and also quality of life (QoL). The aim of this study was to test weight loss and impact on QoL after sibutramine treatment in obese subjects. <i>Methods:<\/i> Double-blind randomized trial on 309 outpatients (51 males, 258 females; age 41.8 \u00b1 10.9 years, BMI 35.0 \u00b1 3.1 kg\/m<sup>2<\/sup>) randomized to sibutramine (n = 154) or to placebo (n = 155) treatment. A combination of sibutramine 10 mg or matching placebo and a balanced hypocaloric diet was given for 6 months with monthly evaluations. The main outcome measures were weight loss, the impact of weight on QoL, BMI, and waist circumference. <i>Results:<\/i> The mean weight reduction was 8.2 kg in the sibutramine group and 3.9 in the placebo group at 6 months (p < 0.01). 40% of the sibutramine subjects and 14% of the control subjects lost \u226710% of their body weight (p < 0.01). The improvement in the impact of weight on QoL was statistically significant only in the sibutramine group at 6 months (mean \u201312.5 vs. \u20134.5 points; p < 0.01). In the sibutramine group the reduction in BMI (\u20133.1 vs. \u20131.4 kg\/m<sup>2<\/sup>) and waist circumference (7.7 vs. 3.5 cm) was significantly greater (p < 0.001). The incidence of adverse events was low and similar to the placebo. <i>Conclusions:<\/i> This study confirmed that sibutramine significantly enhances the effect of diet on weight loss, BMI and waist circumference reduction, and showed a significant improvement of QoL.<\/jats:p>","DOI":"10.1159\/000100824","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T09:53:04Z","timestamp":1173865984000},"page":"75-81","source":"Crossref","is-referenced-by-count":17,"title":["Weight Loss and Quality of Life Improvement in Obese Subjects Treated with Sibutramine: A Double-Blind Randomized Multicenter Study"],"prefix":"10.1159","volume":"51","author":[{"given":"V.","family":"Di Francesco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bissoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Zoico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mazzali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Minniti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Salanitri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cancelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Bosello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1753-4887.1998.tb01722.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.282.16.1530"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0033-0620%2899%2970008-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.4.1165"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fjech.52.7.445"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Foby.2000.17"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.282.22.2136"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903491-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2911509-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Foby.2000.8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.23.1.56"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.11.1331"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2898%2900411-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2F0022-4537.00113"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijo.0802591"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:54:49Z","timestamp":1745463289000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100824","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}