{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:36:51Z","timestamp":1783057011594,"version":"3.54.6"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; We tried to prove the effectiveness of trimetazidine (TMZ) on testicular torsion-detorsion injury. &lt;i&gt;Materials and Methods:&lt;\/i&gt; 15 male rats were equally divided into three groups: group 1 was the sham-operated control group; group 2 had 2 h of unilateral testicular ischemia followed by 3 days of reperfusion, and group 3 had 2 h of unilateral testicular ischemia followed by 3 days of oral TMZ treatment (5 mg\/kg, bid) during reperfusion. In the removed testicles, tissue reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), malondialdehyde (MDA) levels and pathological modified Johnson scores (MJS) were evaluated. Mann-Whitney U test was used for statistical evaluations. &lt;i&gt;Results:&lt;\/i&gt; In group 2, on the ipsilateral side, GSH were significantly lower and MDA were higher than in groups 1 and 3, though GSH and MDA were not statistically different between groups 1 and 3. On the other hand, GPx in the control testicles of group 3 was significantly lower compared to those in the counterparts of both groups 1 and 2. Among three groups, GR determined in both testicles were not statistically different. On the ipsilateral side, MJS in group 3 were lower than in the sham group, but significantly higher than in group 2. &lt;i&gt;Conclusions:&lt;\/i&gt; According to this study, TMZ has an antioxidant effect on testicular torsion-detorsion injury, though the protective effect of TMZ seems to decrease in control testicles. Consequently it has been considered that TMZ can be only used in torsion patients with a healthy contralateral testicle after further studies have been conducted.<\/jats:p>","DOI":"10.1159\/000100842","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T12:29:04Z","timestamp":1178713744000},"page":"356-362","source":"Crossref","is-referenced-by-count":9,"title":["Protective Effects of Trimetazidine on Testicular Ischemia-Reperfusion Injury in Rats"],"prefix":"10.1159","volume":"78","author":[{"given":"Dogan","family":"Unal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer F.","family":"Karatas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Savas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Yeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent S.","family":"Keser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Verit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muharrem","family":"Bitiren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-005-1365-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-004-1317-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2003.031310"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00395-004-0505-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9861%2859%2990090-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080%2F003655902317259391"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00345-004-0451-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1358%2Fmf.2003.25.10.793329"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2004.00365.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phrs.2004.06.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS104366180200172X"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:54:57Z","timestamp":1745463297000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100842","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}