{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:01:13Z","timestamp":1790614873159,"version":"4.1.0"},"reference-count":46,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; No data exist as to Th2 chemokines in erythema multiforme (EM) and Stevens-Johnson syndrome (SJS)\/toxic epidermal necrolysis (TEN). &lt;i&gt;Objective:&lt;\/i&gt; To evaluate thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and regulated upon activation, normal T-lymphocyte-expressed and secreted chemokine (RANTES) expression in EM and SJS\/TEN and to correlate with the serum levels of the Th1 promoter interleukin (IL)-12 and soluble Fas ligand (sFasL). &lt;i&gt;Materials and Methods:&lt;\/i&gt; IL-12, sFasL, TARC, MDC and RANTES expression were analyzed by ELISA techniques in 31 untreated EM (n = 24) or SJS\/TEN (n = 7) patients and in 28 healthy donors (HD). &lt;i&gt;Results:&lt;\/i&gt; EM and SJS\/TEN exhibited significantly higher levels of TARC, IL-12 and sFasL with respect to HD. TARC upregulation paralleled both the IL-12 (p = 0.0225) and sFasL increase (p = 0.0194). &lt;i&gt;Conclusions:&lt;\/i&gt; Our results support a role of TARC in the pathophysiology of EM\/SJS\/TEN and confirm the coexistence of a Th2 response in addition to the predominant Th1 profile.<\/jats:p>","DOI":"10.1159\/000100880","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T11:59:56Z","timestamp":1177502396000},"page":"296-304","source":"Crossref","is-referenced-by-count":27,"title":["Serum Levels of the Th1 Promoter IL-12 and the Th2 Chemokine TARC Are Elevated in Erythema Multiforme and Stevens-Johnson Syndrome\/Toxic Epidermal Necrolysis and Correlate with Soluble Fas Ligand 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