{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:05:16Z","timestamp":1778940316024,"version":"3.51.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Human HSPG2 participates in the formation of amyloid and tau aggregation in Alzheimer\u2019s disease (AD). &lt;i&gt;HSPG2&lt;\/i&gt; gene is located on a susceptibility region to late-onset AD (LOAD), and considered as a candidate gene for LOAD because of its function and location. We performed an association study between the &lt;i&gt;HSPG2 Bam&lt;\/i&gt;H I polymorphism C\/A of intron 6 and LOAD on 104 patients and 127 healthy controls of Chinese origin. The C allele was more prominent in LOAD patients than in controls, though the difference was not statistically significant. Likewise with the stratification of &lt;i&gt;APOE &lt;\/i&gt;&amp;#917;&lt;i&gt;4&lt;\/i&gt; status, no statistical difference was observed between cases and controls. Our findings suggest that this polymorphism may not represent an additional genetic risk factor for LOAD.<\/jats:p>","DOI":"10.1159\/000100902","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T09:53:04Z","timestamp":1173865984000},"page":"312-315","source":"Crossref","is-referenced-by-count":6,"title":["&lt;i&gt;HSPG2&lt;\/i&gt; Gene C\/A Polymorphism Does Not Confer Susceptibility to Alzheimer\u2019s Disease in Chinese"],"prefix":"10.1159","volume":"23","author":[{"given":"Binbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenguang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0888-7543%2891%2990147-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F8.2.237"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2894%2990031-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.147.5.909"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2802%2900010-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fabbi.1995.1345"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.270.31.18666"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.1997.69062452.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F383550a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2003.08.041"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.30015"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100902","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:55:35Z","timestamp":1745463335000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100902","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}