{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:21:47Z","timestamp":1790968907834,"version":"4.1.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> Few reports have investigated the association of two <i>p53<\/i> polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. <i>Aim:<\/i> To explore the impact of the <i>p53<\/i> PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer. <i>Methods:<\/i> One hundred and eighty-four colorectal tumor patients (124 with adenomas and 60 with adenocarcinoma) and 188 controls (42 subjects with a clean colon, 54 hospital controls and 92 blood donors) from the Italian population were tested for PIN3-Arg72Pro haplotype status. <i>Results:<\/i> A significantly increased risk of colorectal adenomas was observed in patients carrying the PIN3 A2-Pro72 haplotype (OR = 2.02, 95% CI: 1.17\u20133.48; p = 0.01), while those carrying the PIN3 A1-Pro72 haplotype had a significantly increased risk of developing CRC (OR = 3.33; 95% CI: 1.40\u20137.89; p = 0.006). Comparisons of cases with the clean colon control group provided stronger evidence of the associations. A family history of CRC did not affect the risk estimates. No association was observed between the pathologic features of adenomas, the Arg72Pro and PIN3 polymorphisms, and the PIN3-Arg72Pro haplotype. <i>Conclusions:<\/i> Our finding that two different <i>p53<\/i> haplotypes are associated with colorectal adenoma and cancer, respectively, suggests that each of these haplotypes may independently impact on <i>p53<\/i> function(s) within different genetic pathways of colorectal carcinogenesis.<\/jats:p>","DOI":"10.1159\/000100966","type":"journal-article","created":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T11:58:52Z","timestamp":1174391932000},"page":"228-235","source":"Crossref","is-referenced-by-count":20,"title":["Increased Risk of Colorectal Adenomas in Italian Subjects Carrying the <i>p53<\/i> PIN3 A2-Pro72 Haplotype"],"prefix":"10.1159","volume":"74","author":[{"given":"Chiara","family":"Perfumo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Bonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Menichini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Inga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Gismondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Ciferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Percivale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Bianchi Scarr\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Nasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Fronza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Varesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.55.2.74"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.cej.0000136719.42948.5a"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6601007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1207%2Fs15327914nc4802_2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fhumu.10081"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1093"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.11548"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2F75586"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F30400"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000154228"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1207305"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000154275"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00201836"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2802%2900041-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.22057"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F16.7.1461"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2264%28199808%2922%3A4%3C257%3A%3AAID-GCC1%3E3.0.CO%3B2-U"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1089%2F10906570260471859"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.20054"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS1535-6108%2803%2900079-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS1535-6108%2803%2900081-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1158%2F1055-9965.EPI-05-0153"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200007203430301"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109%2F00365528909089217"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Fge.1999.v50.97110"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/100966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:56:10Z","timestamp":1745463370000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000100966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":25,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000100966","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}