{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:57:49Z","timestamp":1779321469017,"version":"3.51.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy. &lt;i&gt;Methods:&lt;\/i&gt; We present the case of a patient with mitochondrial syndrome, consisting of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), whose symptoms were temporally related to statin therapy. &lt;i&gt;Conclusion:&lt;\/i&gt; Statins may provoke symptoms related to MELAS in susceptible individuals.<\/jats:p>","DOI":"10.1159\/000101287","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T06:21:17Z","timestamp":1175149277000},"page":"232-235","source":"Crossref","is-referenced-by-count":45,"title":["Statins Provoking MELAS Syndrome"],"prefix":"10.1159","volume":"57","author":[{"given":"Joseph E.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006%2Ftaap.1997.8131"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.289.13.1681"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1022685929755"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2893%2990129-D"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00127893-200209000-00003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902531-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2897%2989180-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clpt.2005.03.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0009-9236%2895%2990266-X"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:59:07Z","timestamp":1745463547000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101287","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}