{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:46:26Z","timestamp":1789821986247,"version":"4.0.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Interleukin (IL)-17F is a recently discovered cytokine and is derived from a panel of limited cell types, such as activated CD4+ T cells, basophils, and mast cells. IL-17F is known to induce several cytokines and chemokines. However, its involvement in airway inflammation has not been well understood. To this end, the expression of IL-17F and the inhibitory effects of glucocorticoids on its expression in a mouse model of asthma were examined. &lt;i&gt;Methods:&lt;\/i&gt; Five-week-old BALB\/c male mice were sensitized by intraperitoneal injection (i.p.) of ovalbumin (OVA) with alum, and challenged by daily inhalation of aerosolized 1% OVA. 24 h after last challenge (OVA\/OVA), the expression of IL-17F was examined in lung tissues by immunohistochemistry and reverse-transcription polymerase chain reaction. Control mice were sensitized and challenged with saline (Sham\/Sham). In addition, a group of OVA-sensitized mice received i.p. injection of water-soluble dexamethasone (DEX) in saline 1 h before OVA challenge (OVA\/DEX). &lt;i&gt;Results:&lt;\/i&gt; In sham-challenged mice, IL-17F was not expressed in the lungs, while, in contrast, IL-17F was predominantly expressed in bronchial epithelial cells in addition to the infiltrating inflammatory cells in OVA\/OVA mice. Further, the expression of IL-17 F was significantly attenuated by the treatment of mice with DEX. &lt;i&gt;Conclusion:&lt;\/i&gt; These results suggest that bronchial epithelium-derived IL-17F may represent a new pharmacological target for glucocorticoids and may play a role in allergic asthma.<\/jats:p>","DOI":"10.1159\/000101413","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T12:08:42Z","timestamp":1180526922000},"page":"89-94","source":"Crossref","is-referenced-by-count":40,"title":["Expression of Interleukin-17F in a Mouse Model of Allergic Asthma"],"prefix":"10.1159","volume":"143","author":[{"given":"Shintaro","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Kokubu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mio","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Odaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Ieki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shau-Ku","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M910228199"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.2.773"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M008289200"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F20.19.5332"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.12.1346"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00474.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.2008161"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2893%2990545-E"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000085434"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2898%2970008-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.C100641200"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.103.056341"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.03.047"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.10.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.06.00125404"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186%2Far1819"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200406-778OC"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:00:37Z","timestamp":1745463637000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101413","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}