{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:43:57Z","timestamp":1790264637994,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> There is little information about the involvement of galectin-9 (Gal-9) in allergic inflammation. Thus, we investigated the role of Gal-9 in asthma model guinea pigs. <i>Methods:<\/i> Airway resistance (R<sub>aw<\/sub>) was measured using a double-flow plethysmograph system. Gal-9 expression in the lung was assessed by Western blot and immunohistochemistry. Eosinophil chemotactic activity was evaluated in a chamber containing a polyvinylpyrolidone-free membrane. Cell apoptosis was analyzed on a flowcytometry with propidium iodide. <i>Results:<\/i> In cloning guinea pig Gal-9 we identified three isoforms that differ only in the length of their linker peptides, just as with human Gal-9. Guinea pig Gal-9 was found to be a chemoattractant for eosinophils and to promote induction of apoptosis in sensitized but not non-sensitized T lymphocytes. In allergic airway hypersensitivity model, a low level of Gal-9 expression was observed in the nonsensitized\/nonchallenged group, but upregulation was detected at 7 h after challenge and sustained up to 24 h. Such upregulation correlated with elevation of eosinophil peroxidase activity but not with increased R<sub>aw<\/sub>. <i>Conclusions:<\/i> The present results provide evidence that Gal-9 is not involved in airway hypersensitivity, but is partly involved in prolonged eosinophil accumulation in the lung.<\/jats:p>","DOI":"10.1159\/000101414","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T12:08:42Z","timestamp":1180526922000},"page":"95-105","source":"Crossref","is-referenced-by-count":22,"title":["Involvement of Galectin-9 in Guinea Pig Allergic Airway Inflammation"],"prefix":"10.1159","volume":"143","author":[{"given":"Hitomi","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kashio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Shinonaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teizo","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigekatsu","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuomi","family":"Hirashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.10.6416"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.27.16976"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.275.12.8355"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970308-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2891%2990251-I"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.54.8.577"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.all.0000010989.39379.49"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI108385"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fglycob%2F12.3.163"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.febslet.2005.02.054"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1570-0232%2802%2900430-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1254%2Fjjp.75.65"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-1759%2893%2990238-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1254%2Fjjp.70.337"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3835%2899%2900107-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fcyto.990130802"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000053623"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.5.2954"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fglycob%2F12.3.191"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903496-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.11.025"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2F415536a"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fni988"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2Fni987"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038%2Fni1271"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.9.6078"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.272.1.617"}],"container-title":["International 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