{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:48:30Z","timestamp":1790668110687,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Dementia with Lewy bodies (DLB) is a common dementia of the elderly. A significant cholinergic deficit has been demonstrated that may be responsive to treatment by cholinesterase inhibitors (ChEIs). &lt;i&gt;Methods:&lt;\/i&gt; A 24-week, open-label study was designed to assess the efficacy and safety of a ChEI, galantamine, in 50 patients with DLB. &lt;i&gt;Results:&lt;\/i&gt; This study showed beneficial effects with galantamine in 2 of the 3 primary efficacy parameters. The scores on the Neuropsychiatric Inventory (NPI-12) improved by 8.24 points from baseline (p = 0.01) especially in visual hallucinations and nighttime behaviors (p = 0.004). The scores on the Clinician\u2019s Global Impression of Change improved by 0.5 points from baseline (p = 0.01). The third primary efficacy parameter, the Cognitive Drug Research Computerized Cognitive Assessment System, was unchanged from baseline. Adverse events were generally mild and transient. &lt;i&gt;Conclusion:&lt;\/i&gt; Galantamine appears to be an effective and safe therapy for patients with DLB.<\/jats:p>","DOI":"10.1159\/000101512","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T10:00:55Z","timestamp":1176372055000},"page":"401-405","source":"Crossref","is-referenced-by-count":91,"title":["Efficacy and Safety of Galantamine in Patients with Dementia with Lewy Bodies: A 24-Week Open-Label Study"],"prefix":"10.1159","volume":"23","author":[{"given":"Keith","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Royall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hershey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Farlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.47.5.1113"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000187889.17253.b1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-510X%2890%2990236-G"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.44.12.2308"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903399-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2800%2900093-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1471-4159.1999.0731590.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000051227"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fnn769"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2004.09.042"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000074681"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.930060208"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00002093-199700112-00004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00002093-199700112-00005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-1781%2889%2990047-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.177.3.252"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1997.tb00299.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawh725"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000196638.98781.bb"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa052827"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:43Z","timestamp":1745463703000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101512","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}