{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:09:15Z","timestamp":1758946155836,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> \u03b1-Human atrial natriuretic peptide (hANP) reportedly increases in premature infants with patent ductus arteriosus (PDA). <i>Objectives:<\/i> To clarify a possible hANP effect to reopen the postnatal ductus, we studied in vivo reopening of the postnatal DA by a recombinant hANP, carperitide, in rats. <i>Methods:<\/i> Near-term rat pups were incubated at 33\u00b0C following caesarean section. The inner diameter of the ductus was measured with a microscope and a micrometer following rapid whole-body freezing. The DA constricted quickly after birth, and the inner diameter was 0.80 and 0.08 mm at 0 min (fetal state) and 60 min after birth. hANP concentration in the pup blood and the ductus-dilating effect of hANP were studied by subcutaneous injection of hANP at 60 min after birth, and by measurement 7, 15, 30 and 60 min later. <i>Results:<\/i> The peak hANP concentration was 790 pg\/ml at 7 min with 1 mg\/kg, which is similar to the level seen in preterm infants with symptomatic PDA. hANP dilated the postnatal ductus dose dependently and maximally at 7 min after injection. hANP dilated the postnatal constricted ductus completely to 0.79 mm in diameter with a large dose (10 mg\/kg) and to 0.55 mm with 1 mg\/kg. <i>Conclusions:<\/i> hANP reopens the constricted postnatal DA dose dependently in rats. The increased hANP, accompanying premature PDA, may delay closure of the DA.<\/jats:p>","DOI":"10.1159\/000101526","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T10:00:55Z","timestamp":1176372055000},"page":"139-144","source":"Crossref","is-referenced-by-count":14,"title":["In vivo Dilatation of the Postnatal Ductus Arteriosus by Atrial Natriuretic Peptide in the Rat"],"prefix":"10.1159","volume":"92","author":[{"given":"Katsuaki","family":"Toyoshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Momma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-291X%2884%2991077-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-291X%2885%2980051-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-291X%2886%2990295-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2885%2990178-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.62.11.1165"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1992.tb12330.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-994461"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080%2F080352501300049406"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.03.040"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211383"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.69.283"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1536%2Fjhj.42.271"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198009000-00011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000165823"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199909000-00010"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000087541.15600.2B"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2883%2980022-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000156370.50874.3C"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000089954"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2886%2992675-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2810%2980036-1"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jtcvs.2005.03.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1254%2Fjjp.59.489"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:50Z","timestamp":1745463710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101526","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2007]]}}}