{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:18:58Z","timestamp":1779340738785,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Aims:<\/i> It was the aim of this study to describe risk factors in auditory neuropathy\/auditory synaptopathy (AN\/AS). <i>Methods:<\/i> Between 1997 and 2005, we diagnosed 37 children with AN\/AS. They underwent a critical chart review for risk factors and etiological coincidences in this idiosyncratic disorder. <i>Results:<\/i> Eighteen neonates had a history of prematurity and low birth weight. Hyperbilirubinaemia was present in 13 children. Three patients had evidence of infection during pregnancy, and AN\/AS was associated with complex syndromal diseases in 2 cases. A congenital, familial pattern was seen in 2 siblings. Seven patients had idiopathic AN\/AS. <i>Conclusion:<\/i> Rather than being a single etiological entity, AN\/AS comprises a spectrum of risk factors and associated problems affecting the cochlea and the auditory pathway. This study shows that the majority of AN\/AS in children is the result of perinatal problems and is not genetic in origin. Hyperbilirubinaemia is a common and etiologically significant finding in infants suffering from AN\/AS. Thus, early hearing screening for AN\/AS including transient evoked otoacoustic emissions and auditory brainstem response assessment among neonates with risk factors for AN\/AS is crucial in order to better manage patients suffering from this disorder.<\/jats:p>","DOI":"10.1159\/000101545","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T10:00:55Z","timestamp":1176372055000},"page":"239-244","source":"Crossref","is-referenced-by-count":39,"title":["Risk Factors for Auditory Neuropathy\/Auditory Synaptopathy"],"prefix":"10.1159","volume":"69","author":[{"given":"Dirk","family":"Beutner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Foerst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lang-Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasso","family":"von Wedel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Walger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109%2F00206097909072636"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00003446-198009000-00009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F114.3.1157"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00003446-199806000-00001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F119.3.741"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00003446-199810000-00002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature03418"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mao.0000169044.63970.4a"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijporl.2006.02.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1288%2F00005537-198403000-00019"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0028-1083049"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-5597%2896%2996635-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097%2F00003446-199906000-00006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pediatrneurol.2003.09.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00005537-200309000-00041"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawg156"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.40.1.45"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177%2F108471380500900102"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-5955%2893%2990199-B"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5876%2803%2900103-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-2806"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2981211-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F01.MLG.0000181501.80291.05"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00129492-200407000-00016"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:02:05Z","timestamp":1745463725000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101545","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}