{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:07:50Z","timestamp":1750158470366,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background and Objectives:<\/i> Since gastric acidity and ascorbate play a critical role in the solubilization and reduction of iron for subsequent absorption, the achlorhydria associated with autoimmune and <i>Helicobacter pylori<\/i> gastritis may explain the poor response of such patients to oral iron treatment. In order to circumvent this problem, we explored the therapeutic potential of a duodenal formulation of ferrous glycine sulfate consisting of micropellets that do not dissolve at the acid environment of the stomach but, owing to their solubility at a higher pH, discharge their content directly into the duodenum. <i>Design and Methods:<\/i> In a case-control study, the treatment results of 39 patients with iron deficiency anemia receiving a duodenal formulation of ferrous glycine sulfate (group A) were compared with the results of 39 patients receiving other oral iron compounds (group B). Autoimmune gastritis, <i>H. pylori <\/i>gastritis or both were present in over 75% of patients in each group. <i>Results:<\/i> After 1 and 3 months of treatment, mean hemoglobin in group A increased from 9.5 \u00b1 1.2 to 11.2 \u00b1 1.3 and 12.8 \u00b1 1.3 g\/dl, respectively. By comparison, in group B, the corresponding values increased from 9.3 \u00b1 1.3 to 10.2 \u00b1 1.5 (p = 0.019) and 11.1 \u00b1 1.7 g\/dl (p = 0.022). A favorable response, defined as a more than 2 g\/dl increase in basal hemoglobin or hemoglobin exceeding 12 g\/dl, was obtained in 33 of 39 patients in group A compared with only 18 of 39 in group B (p = 0.009). Because of treatment failure, 14 patients in group B were subsequently referred for intravenous ferric sucrose therapy versus only 3 in group A (p < 0.0001). Conversely, of 5 patients in group A managed by intravenous iron prior to referral, 4 became independent of parenteral iron after starting the duodenal formulation of ferrous glycine sulfate. <i>Interpretation and Conclusions:<\/i> In patients with iron deficiency anemia associated with autoimmune and <i>H. pylori<\/i> gastritis with a high rate of refractoriness to oral iron treatment, satisfactory response to a duodenal formulation of ferrous glycine sulfate can be elicited in the vast majority of cases, obviating the need for expensive, inconvenient and occasionally risky intravenous iron administration.<\/jats:p>","DOI":"10.1159\/000101701","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T10:00:55Z","timestamp":1176372055000},"page":"19-26","source":"Crossref","is-referenced-by-count":6,"title":["Decreased Treatment Failure Rates following Duodenal Release Ferrous Glycine Sulfate in Iron Deficiency Anemia Associated with Autoimmune Gastritis and <i>Helicobacter pylori<\/i> Gastritis"],"prefix":"10.1159","volume":"118","author":[{"given":"Chaim","family":"Hershko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Ianculovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Souroujon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1018896015530"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080%2F00365529850172368"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01348.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00005176-200007000-00012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-5378.1999.98066.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2001.114700"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529709025083"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2801%2900883-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-09-3534"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bcmd.2006.09.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.4.496"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2897%2970075-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI105002"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.4.5682.531"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM196209132671104"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1537-2995.2004.04045.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2005.00250.x"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:04:28Z","timestamp":1745463868000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101701","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2007]]}}}