{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T02:28:50Z","timestamp":1759026530053,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>We focus on the roles of decidual and cumulus oophorus T cells. It was suggested that Th1-type cytokines (IFN-\u03b3 and TNF-\u03b2), which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-5, IL-10) inhibiting the Th1 responses promote allograft tolerance and therefore may improve fetal survival. We found that T cells\u2019 leukemia inhibitory factor (LIF), M-CSF, IL-4 and IL-10 production at the fetomaternal interface could contribute to the maintenance of pregnancy. Interestingly, we did not find an increased production of IFN-\u03b3 by decidual T cells during spontaneous abortion, as expected. We detected T cells in the cumulus oophorus, which surrounds the oocyte during ovulation and the egg before implantation. Cumulus oophorus T cells produce higher levels of IL-4 and LIF than the T cells of peripheral blood or the ovary. We can only speculate what the factors present in the microenvironment of the T cells are that could be responsible for the cytokine profile of decidual and cumulus oophorus T cells. Hormones present in the decidua and in the cumulus oophorus could be the first candidates. In particular, progesterone is a potent inducer of production of Th2-type cytokines, LIF and M-CSF. Other candidates could be molecules produced by the trophoblast or the embryo.<\/jats:p>","DOI":"10.1159\/000101738","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T10:10:36Z","timestamp":1192183836000},"page":"144-148","source":"Crossref","is-referenced-by-count":18,"title":["Role of T-Cell Cytokines in Decidua and in Cumulus Oophorus during Pregnancy"],"prefix":"10.1159","volume":"64","author":[{"given":"Marie-Pierre","family":"Piccinni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2891%2990120-I"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2893%2990235-D"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2005.00892.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbmt.2004.06.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01541085"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-7915%2896%2980087-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0952-7915%2894%2990081-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.273.24.1933"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F15.3.713"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2F2006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeg280"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.2.217"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F359076a0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod60.2.355"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F1521-4141%28200108%2931%3A8%3C2431%3A%3AAID-IMMU2431%3E3.0.CO%3B2-U"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod46.3.470"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02211386"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-0378%2801%2900111-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199907%2929%3A07%3C2241%3A%3AAID-IMMU2241%3E3.0.CO%3B2-E"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:04:50Z","timestamp":1745463890000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101738","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2007]]}}}