{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:29:12Z","timestamp":1777436952805,"version":"3.51.4"},"reference-count":41,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Methods:&lt;\/i&gt; We have examined the hypothesis that cyst formation is key in the pathogenesis of cardiovascular disease in a Lewis polycystic kidney (LPK) model of autosomal-recessive polycystic kidney disease (ARPKD), by determining the relationship between cyst development and indices of renal function and cardiovascular disease. &lt;i&gt;Results:&lt;\/i&gt; In the LPK (n = 35), cysts appear at week 3 (1.1 \u00b1 0.1 mm) increasing to week 24 (2.8 \u00b1 2 mm). Immunostaining for nephron-specific segments indicate cysts develop predominantly from the collecting duct. Cyst formation preceded hypertension (160 \u00b1 22 vs. Lewis control 105 \u00b1 20 mm Hg systolic blood pressure (BP), n = 12) at week 6, elevated creatinine (109 \u00b1 63 vs. 59 \u00b1 6 \u00b5mol\/l, n = 16) and cardiac mass (0.7 vs. 0.4% bodyweight, n = 15) at week 12, and left ventricular hypertrophy (2,898 \u00b1 207 vs. 1,808 \u00b1 192 \u00b5m, n = 14) at week 24 (all p \u2264 0.05). Plasma-renin activity and angiotensin II were reduced in 10- to 12-week LPK (2.2 \u00b1 2.9 vs. Lewis 11.9 \u00b1 4.9 ng\/ml\/h, and 25.0 \u00b1 19.1 vs. 94.9 \u00b1 64.4 pg\/ml, respectively, n = 26, p \u2264 0.05). Ganglionic blockade (hexamethonium 3.3 mg\/kg) significantly reduced mean BP in the LPK (52 vs. Lewis 4%, n = 9, p \u2264 0.05). &lt;i&gt;Conclusion:&lt;\/i&gt; Cyst formation is a key event in the genesis of hypertension while the sympathetic nervous system is important in the maintenance of hypertension in this model of ARPKD.<\/jats:p>","DOI":"10.1159\/000101828","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T10:28:54Z","timestamp":1177064934000},"page":"129-144","source":"Crossref","is-referenced-by-count":76,"title":["Temporal Relationship between Renal Cyst Development, Hypertension and Cardiac Hypertrophy in a New Rat Model of Autosomal Recessive Polycystic Kidney Disease"],"prefix":"10.1159","volume":"30","author":[{"given":"Jacqueline 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