{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:12:38Z","timestamp":1791051158150,"version":"4.1.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"The sigma-1 receptor (SIGMAR1) is a subtype of a nonopioid sigma receptor family and is implicated in numerous functions connected with Alzheimer\u2019s disease (AD). Two common genetic variants were identified in <i>SIGMAR1:<\/i> GC\u2013241 \u2013240TT and Q2P (A61C). It was suggested that the TT-C haplotype is a protective factor for AD. We decided to investigate a putative link between the variants of <i>SIGMAR1<\/i> and AD in a group of Polish patients with late-onset AD, in patients with mild cognitive impairment, and in a control group. We observed no significant differences for the <i>SIGMAR1<\/i> allele, genotype, haplotype, and diplotype distributions between the studied groups. Multivariate logistic regression analysis showed no interaction between the <i>APOE4<\/i> and <i>SIGMAR1<\/i> polymorphisms. Further studies using data from different populations are required to elucidate the effect of <i>SIGMAR1<\/i> polymorphisms on AD.<\/jats:p>","DOI":"10.1159\/000101990","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T07:59:56Z","timestamp":1177487996000},"page":"432-438","source":"Crossref","is-referenced-by-count":32,"title":["Sigma Receptor Type 1 Gene Variation in a Group of Polish Patients with Alzheimer\u2019s Disease and Mild Cognitive 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